STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemLTIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase: (4.9e-217); PFAM: aminotransferase class-III: (3.9e-73); KEGG: dra:DR0555 glutamate-1-semialdehyde 2,1-aminomutase, ev=0.0, 74% identity. (457 aa)    
Predicted Functional Partners:
Dgeo_0882
Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase: (2.8e-187); KEGG: dra:DR2160 delta-aminolevulinic acid dehydratase, ev=1e-137, 75% identity; Belongs to the ALAD family.
 
 
 0.992
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
 0.990
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
  
 0.919
Dgeo_2131
TIGRFAM: uroporphyrin-III C-methyltransferase: (9e-132); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase: (6.1e-80) Uroporphyrinogen III synthase HEM4: (1e-26); KEGG: dra:DRA0011 uroporphyrin-III synthase / uroporphyrin-III C-methyltransferase, ev=1e-147, 60% identity.
 
  
 0.856
Dgeo_1943
PFAM: CoA-binding: (0.0017); KEGG: dra:DR0556 hypothetical protein, ev=2e-57, 71% identity.
       0.840
Dgeo_1941
KEGG: dra:DR0554 hypothetical protein, ev=2e-63, 55% identity.
       0.799
Dgeo_2129
Precorrin-2 dehydrogenase; TIGRFAM: siroheme synthase, N-terminal domain: (1.4e-19); KEGG: cvi:CV0813 uroporphyrin-III C-methyltransferase, ev=2e-23, 46% identity.
 
   
 0.713
Dgeo_0434
TIGRFAM: malonyl CoA-acyl carrier protein transacylase: (1.8e-118); PFAM: acyl transferase region: (1.8e-14); KEGG: dra:DR1945 malonyl CoA-acyl carrier protein transacylase, ev=1e-126, 76% identity.
    
 0.631
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
     
 0.536
Dgeo_0300
5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
     
 0.490
Your Current Organism:
Deinococcus geothermalis
NCBI taxonomy Id: 319795
Other names: D. geothermalis DSM 11300, Deinococcus geothermalis AG-3a, Deinococcus geothermalis CIP 105573, Deinococcus geothermalis DSM 11300, Deinococcus geothermalis str. DSM 11300, Deinococcus geothermalis strain DSM 11300
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