STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nrdRRibonucleotide reductase regulator NrdR-like protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (150 aa)    
Predicted Functional Partners:
Dgeo_2034
PFAM: short-chain dehydrogenase/reductase SDR: (1.4e-05); KEGG: dra:DR0088 oxidoreductase, short-chain dehydrogenase/reductase family, ev=3e-79, 64% identity.
       0.785
Dgeo_2035
Hypothetical protein.
       0.769
Dgeo_0300
5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
  
  
 0.702
ribBA
3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
     
 0.601
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
     
 0.549
Dgeo_2037
DnaB-like protein helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily.
       0.509
Dgeo_2036
PFAM: NUDIX hydrolase: (1.3e-28); KEGG: dra:DR0550 MutT/NUDIX family protein, ev=2e-94, 80% identity; Belongs to the Nudix hydrolase family.
     
 0.492
Dgeo_2140
TIGRFAM: Biotin--acetyl-CoA-carboxylase ligase: (9.3e-34) Helix-turn-helix biotin operon repressor region: (3.4e-19); PFAM: biotin protein ligase-like: (5.6e-05) biotin/lipoate A/B protein ligase: (1.8e-16); KEGG: dra:DR2341 birA bifunctional protein, ev=1e-111, 69% identity.
     
 0.469
argR
Arginine repressor, ArgR; Regulates arginine biosynthesis genes.
      
 0.428
Your Current Organism:
Deinococcus geothermalis
NCBI taxonomy Id: 319795
Other names: D. geothermalis DSM 11300, Deinococcus geothermalis AG-3a, Deinococcus geothermalis CIP 105573, Deinococcus geothermalis DSM 11300, Deinococcus geothermalis str. DSM 11300, Deinococcus geothermalis strain DSM 11300
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