STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
unguracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (245 aa)    
Predicted Functional Partners:
Dgeo_0461
KEGG: dra:DR0354 exodeoxyribonuclease III, ev=1e-100, 70% identity; TIGRFAM: exodeoxyribonuclease III: (3.6e-54) exodeoxyribonuclease III (xth): (5.4e-65); PFAM: Endonuclease/exonuclease/phosphatase: (1.2e-47).
   
 0.876
Dgeo_2058
DNA topoisomerase IB; KEGG: dra:DR0690 type I topoisomerase, putative, ev=1e-144, 74% identity.
     
 0.858
Dgeo_0003
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 
 0.667
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
      0.640
nth
DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
  
 
 0.597
carA
TIGRFAM: carbamoyl-phosphate synthase, small subunit: (6.3e-239); PFAM: glutamine amidotransferase class-I: (1.9e-65) Carbamoyl-phosphate synthase, small chain: (1.3e-72); KEGG: dra:DR0684 carbamoyl-phosphate synthase small chain, ev=0.0, 95% identity; Belongs to the CarA family.
       0.573
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
   
 
 0.517
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.502
Dgeo_1579
TIGRFAM: DNA internalization-related competence protein ComEC/Rec2: (7e-56); PFAM: beta-lactamase-like: (1.2e-06) ComEC/Rec2-related protein: (5.8e-44); KEGG: dra:DR1854 competence protein ComEC/Rec2, putative, ev=0.0, 68% identity.
     
 0.407
Your Current Organism:
Deinococcus geothermalis
NCBI taxonomy Id: 319795
Other names: D. geothermalis DSM 11300, Deinococcus geothermalis AG-3a, Deinococcus geothermalis CIP 105573, Deinococcus geothermalis DSM 11300, Deinococcus geothermalis str. DSM 11300, Deinococcus geothermalis strain DSM 11300
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