STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hisAPhosphorybosilformimino-5-amino-phosphorybosil- 4-imidazolecarboxamideisomerase; Similar to all4506 of Nostoc sp. PCC 7120. (256 aa)    
Predicted Functional Partners:
hisIE
Phosphoribosyl-AMP cyclohydrolase and Phosphoribosyl-ATP pyrophosphatase; Simislar to slr0608 of Synechocystis sp. PCC 6803; In the N-terminal section; belongs to the PRA-CH family.
 
 0.999
hisH
Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
 
 0.997
hisF
Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
 
0.993
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
 0.990
hisB-2
Imidazoleglycerol-phosphate dehydratase; Similar to all4390 of Nostoc sp. PCC 7120.
 
  
 0.978
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
 
  
 0.976
hisC
Histidinol-phosphate amidotransferase; Similar to all4966 of Nostoc sp. PCC 7120; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
  
 0.936
hisZ
ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
  
  
 0.874
frk
PfkB family of carbohydrate kinases; probable fructokinase.
  
    0.787
guaA
GMP synthetase; Catalyzes the synthesis of GMP from XMP.
  
  
 0.778
Your Current Organism:
Synechococcus sp. PCC7002
NCBI taxonomy Id: 32049
Other names: Agmenellum quadruplicatum, Agmenellum quadruplicatum PR-6, S. sp. PCC 7002, Synechococcus PCC7002 PR-6, Synechococcus sp. (ATCC 27264), Synechococcus sp. (PCC 7002), Synechococcus sp. (strain PCC 7002), Synechococcus sp. PCC 7002
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