node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cobD-2 | hisA | CYA_0941 | CYA_2513 | L-threonine-O-3-phosphate decarboxylase; Identified by similarity to GB:AAC79515.1; match to protein family HMM PF00155; match to protein family HMM TIGR01140. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | 0.854 |
cobD-2 | hisB | CYA_0941 | CYA_2626 | L-threonine-O-3-phosphate decarboxylase; Identified by similarity to GB:AAC79515.1; match to protein family HMM PF00155; match to protein family HMM TIGR01140. | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | 0.903 |
cobD-2 | hisD | CYA_0941 | CYA_0591 | L-threonine-O-3-phosphate decarboxylase; Identified by similarity to GB:AAC79515.1; match to protein family HMM PF00155; match to protein family HMM TIGR01140. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.944 |
cobD-2 | hisF | CYA_0941 | CYA_2282 | L-threonine-O-3-phosphate decarboxylase; Identified by similarity to GB:AAC79515.1; match to protein family HMM PF00155; match to protein family HMM TIGR01140. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.882 |
cobD-2 | hisG | CYA_0941 | CYA_1232 | L-threonine-O-3-phosphate decarboxylase; Identified by similarity to GB:AAC79515.1; match to protein family HMM PF00155; match to protein family HMM TIGR01140. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.847 |
cobD-2 | hisH | CYA_0941 | CYA_0969 | L-threonine-O-3-phosphate decarboxylase; Identified by similarity to GB:AAC79515.1; match to protein family HMM PF00155; match to protein family HMM TIGR01140. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.915 |
cobD-2 | hisIE | CYA_0941 | CYA_0504 | L-threonine-O-3-phosphate decarboxylase; Identified by similarity to GB:AAC79515.1; match to protein family HMM PF00155; match to protein family HMM TIGR01140. | Histidine biosynthesis bifunctional protein HisIE; Identified by similarity to SP:O34912; match to protein family HMM PF01502; match to protein family HMM PF01503; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
cobD-2 | hisZ | CYA_0941 | CYA_1524 | L-threonine-O-3-phosphate decarboxylase; Identified by similarity to GB:AAC79515.1; match to protein family HMM PF00155; match to protein family HMM TIGR01140. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.762 |
guaA | hisA | CYA_1673 | CYA_2513 | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | 0.768 |
guaA | hisF | CYA_1673 | CYA_2282 | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.483 |
guaA | hisH | CYA_1673 | CYA_0969 | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.489 |
hisA | cobD-2 | CYA_2513 | CYA_0941 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | L-threonine-O-3-phosphate decarboxylase; Identified by similarity to GB:AAC79515.1; match to protein family HMM PF00155; match to protein family HMM TIGR01140. | 0.854 |
hisA | guaA | CYA_2513 | CYA_1673 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | GMP synthase, glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | 0.768 |
hisA | hisB | CYA_2513 | CYA_2626 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | 0.989 |
hisA | hisC | CYA_2513 | CYA_1885 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.892 |
hisA | hisD | CYA_2513 | CYA_0591 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.995 |
hisA | hisF | CYA_2513 | CYA_2282 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.996 |
hisA | hisG | CYA_2513 | CYA_1232 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.988 |
hisA | hisH | CYA_2513 | CYA_0969 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisIE | CYA_2513 | CYA_0504 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | Histidine biosynthesis bifunctional protein HisIE; Identified by similarity to SP:O34912; match to protein family HMM PF01502; match to protein family HMM PF01503; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |