STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
hisCHistidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (353 aa)    
Predicted Functional Partners:
hisB
Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475.
 
 0.999
hisIE
Histidine biosynthesis bifunctional protein HisIE; Identified by match to protein family HMM PF01502; match to protein family HMM PF01503; In the N-terminal section; belongs to the PRA-CH family.
 
  
 0.997
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
 0.994
tyrA
Prephenate dehydrogenase; Identified by similarity to SP:P20692; match to protein family HMM PF02153; match to protein family HMM PF02254; match to protein family HMM PF02558; match to protein family HMM PF02737; match to protein family HMM PF03446; match to protein family HMM PF03807.
  
 
 0.973
hisH
Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.929
hisF
Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
  
 0.923
pheA
Prephenate dehydratase; Identified by match to protein family HMM PF00800; match to protein family HMM PF01842.
  
 
 0.920
aspC
Aspartate aminotransferase; Identified by similarity to SP:Q59228; match to protein family HMM PF00155.
  
 
 0.918
CYB_0246
4-hydroxyphenylpyruvate dioxygenase, putative; Identified by match to protein family HMM PF00903.
    
 0.914
CYB_2462
Identified by match to protein family HMM PF00459.
  
 
 0.905
Your Current Organism:
Synechococcus sp. JA23Ba
NCBI taxonomy Id: 321332
Other names: Cyanobacteria bacterium Yellowstone B-Prime, S. sp. JA-2-3B'a(2-13), Synechococcus sp. JA-2-3B'a(2-13)
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