Genes that are sometimes fused into single open reading frames.
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
annotation not available (155 aa)
Predicted Functional Partners:
Carboxypeptidase; Belongs to the peptidase S10 family (461 aa)
Delta-1-pyrroline-5-carboxylate synthase; P5CS plays a key role in proline biosynthesis, leading to osmoregulation in plants; In the N-terminal section; belongs to the glutamate 5- kinase family (757 aa)
annotation not available (566 aa)
Thioredoxin reductase ; Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family (573 aa)
Predicted protein; Imidazole glycerol phosphate synthase subunit hisF ; Belongs to the HisA/HisF family (617 aa)
Imidazoleglycerol-phosphate dehydratase ; Belongs to the imidazoleglycerol-phosphate dehydratase family (332 aa)
Predicted protein (512 aa)
Predicted protein (511 aa)
Predicted protein; Belongs to the HisA/HisF family (324 aa)
Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (632 aa)