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CTU1 protein (Physcomitrella patens) - STRING interaction network
"CTU1" - Predicted protein in Physcomitrella patens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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CTU1Predicted protein; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position (348 aa)    
Predicted Functional Partners:
PP1S34_86V6.1
Annotation not available (492 aa)
     
  0.997
PP1S43_232V6.1
Imidazole glycerol phosphate synthase subunit hisF (617 aa)
   
 
  0.898
PP1S99_92V6.1
Predicted protein; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2- thiolation reaction by being thiocarboxylated (-COSH) at its C- terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces [...] (99 aa)
       
  0.879
HAG1502
RNA polymerase II elongator complex, subunit ELP3/histone acetyltransferase (569 aa)
     
 
  0.832
PP1S167_46V6.1
Annotation not available (552 aa)
     
 
  0.832
PP1S54_48V6.2
Predicted protein (522 aa)
   
   
  0.803
PP1S37_39V6.1
Annotation not available (1067 aa)
         
  0.705
PP1S213_9V6.1
Predicted protein (533 aa)
     
  0.695
PP1S189_99V6.1
Predicted protein (535 aa)
     
  0.695
CNX5
Predicted protein; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the pers [...] (467 aa)
   
 
  0.695
Your Current Organism:
Physcomitrella patens
NCBI taxonomy Id: 3218
Other names: Bryophyta, Bryophytina, Bryopsida, Funariaceae, Funariales, Funariidae, Moss Superclass V, Musci, P. patens, Physcomitrella, Physcomitrella Bruch & Schimp, Physcomitrella patens, Physcomitrella patens (Hedw.) Bruch & Schimp., Physcomitrium patens, Physcomitrium patens (Hedw.) Mitt., bryophytes, mosses
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