node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cobA | cysC1 | Avin_28170 | Avin_16180 | Uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | 0.931 |
cobA | cysC2 | Avin_28170 | Avin_00500 | Uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Adenylylsulfate kinase, C-terminal domain protein; Catalyzes the synthesis of activated sulfate. | 0.931 |
cobA | cysD | Avin_28170 | Avin_12970 | Uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Phosphoadenosine phosphosulfate reductase/sulfate adenyltransferase subunit 2. | 0.951 |
cobA | cysH | Avin_28170 | Avin_23150 | Uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Phosphoadenosine phosphosulfate reductase CysH-type; Reduction of activated sulfate into sulfite. | 0.984 |
cobA | cysI | Avin_28170 | Avin_27520 | Uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Sulfite reductase, beta subunit (hemoprotein). | 0.991 |
cobA | cysN | Avin_28170 | Avin_12980 | Uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Adenylylsulfate kinase/ Sulfate Adenylyltransferase subunit 1; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 0.964 |
cobA | hemC | Avin_28170 | Avin_47600 | Uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.988 |
cobA | hemD | Avin_28170 | Avin_47590 | Uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.960 |
cobA | hemE | Avin_28170 | Avin_45190 | Uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.952 |
cobA | nasH | Avin_28170 | Avin_23340 | Uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Uroporphyrin-III C-methyltransferase, NasH. | 0.963 |
cysC1 | cobA | Avin_16180 | Avin_28170 | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | Uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.931 |
cysC1 | cysD | Avin_16180 | Avin_12970 | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | Phosphoadenosine phosphosulfate reductase/sulfate adenyltransferase subunit 2. | 0.988 |
cysC1 | cysH | Avin_16180 | Avin_23150 | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | Phosphoadenosine phosphosulfate reductase CysH-type; Reduction of activated sulfate into sulfite. | 0.994 |
cysC1 | cysI | Avin_16180 | Avin_27520 | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | Sulfite reductase, beta subunit (hemoprotein). | 0.874 |
cysC1 | cysN | Avin_16180 | Avin_12980 | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | Adenylylsulfate kinase/ Sulfate Adenylyltransferase subunit 1; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 0.972 |
cysC1 | nasH | Avin_16180 | Avin_23340 | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | Uroporphyrin-III C-methyltransferase, NasH. | 0.540 |
cysC2 | cobA | Avin_00500 | Avin_28170 | Adenylylsulfate kinase, C-terminal domain protein; Catalyzes the synthesis of activated sulfate. | Uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.931 |
cysC2 | cysD | Avin_00500 | Avin_12970 | Adenylylsulfate kinase, C-terminal domain protein; Catalyzes the synthesis of activated sulfate. | Phosphoadenosine phosphosulfate reductase/sulfate adenyltransferase subunit 2. | 0.988 |
cysC2 | cysH | Avin_00500 | Avin_23150 | Adenylylsulfate kinase, C-terminal domain protein; Catalyzes the synthesis of activated sulfate. | Phosphoadenosine phosphosulfate reductase CysH-type; Reduction of activated sulfate into sulfite. | 0.994 |
cysC2 | cysI | Avin_00500 | Avin_27520 | Adenylylsulfate kinase, C-terminal domain protein; Catalyzes the synthesis of activated sulfate. | Sulfite reductase, beta subunit (hemoprotein). | 0.874 |