STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
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[Homology]
Score
glnDUTP-GlnB (protein PII) uridylyltransferase, GlnD; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. (931 aa)    
Predicted Functional Partners:
Nham_2233
Nitrogen regulatory protein P-II; Belongs to the P(II) protein family.
 
 
 0.965
glnE
Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]
 
   
 0.762
Nham_0085
Nitrogen regulatory protein P-II (GlnB, GlnK); Belongs to the P(II) protein family.
 
 
 
 0.640
Nham_0086
Nitrogen regulatory protein P-II; Belongs to the P(II) protein family.
 
 
 
 0.635
Nham_1836
Signal transduction histidine kinase, nitrogen specific, NtrB.
  
 
 
 0.577
Nham_1138
Glutamate synthase (NADH) large subunit.
     
 0.532
bamA
Surface antigen (D15); Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
 
    0.516
Nham_2234
L-glutamine synthetase.
 
   
 0.512
Nham_0225
OsmC-like protein.
       0.467
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
   
  
 0.426
Your Current Organism:
Nitrobacter hamburgensis
NCBI taxonomy Id: 323097
Other names: N. hamburgensis X14, Nitrobacter hamburgensis X14, Nitrobacter hamburgensis str. X14, Nitrobacter hamburgensis strain X14
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