node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Nwi_0042 | Nwi_0043 | Nwi_0042 | Nwi_0043 | 2-octaprenylphenol hydroxylase. | Phosphopantothenate-cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.754 |
Nwi_0042 | Nwi_0045 | Nwi_0042 | Nwi_0045 | 2-octaprenylphenol hydroxylase. | Histidine kinase. | 0.641 |
Nwi_0042 | Nwi_0046 | Nwi_0042 | Nwi_0046 | 2-octaprenylphenol hydroxylase. | Protein of unknown function UPF0079. | 0.544 |
Nwi_0042 | Nwi_1725 | Nwi_0042 | Nwi_1725 | 2-octaprenylphenol hydroxylase. | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.529 |
Nwi_0042 | Nwi_2616 | Nwi_0042 | Nwi_2616 | 2-octaprenylphenol hydroxylase. | Cytochrome c1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. | 0.572 |
Nwi_0042 | dut | Nwi_0042 | Nwi_0044 | 2-octaprenylphenol hydroxylase. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.634 |
Nwi_0042 | mutM | Nwi_0042 | Nwi_0040 | 2-octaprenylphenol hydroxylase. | DNA-(apurinic or apyrimidinic site) lyase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.591 |
Nwi_0042 | ubiA | Nwi_0042 | Nwi_2562 | 2-octaprenylphenol hydroxylase. | 4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.532 |
Nwi_0042 | ubiE | Nwi_0042 | Nwi_0041 | 2-octaprenylphenol hydroxylase. | 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). | 0.811 |
Nwi_0042 | ubiG | Nwi_0042 | Nwi_0381 | 2-octaprenylphenol hydroxylase. | 3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. | 0.844 |
Nwi_0043 | Nwi_0042 | Nwi_0043 | Nwi_0042 | Phosphopantothenate-cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 2-octaprenylphenol hydroxylase. | 0.754 |
Nwi_0043 | Nwi_0045 | Nwi_0043 | Nwi_0045 | Phosphopantothenate-cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Histidine kinase. | 0.521 |
Nwi_0043 | Nwi_0046 | Nwi_0043 | Nwi_0046 | Phosphopantothenate-cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Protein of unknown function UPF0079. | 0.564 |
Nwi_0043 | Nwi_1725 | Nwi_0043 | Nwi_1725 | Phosphopantothenate-cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.634 |
Nwi_0043 | dut | Nwi_0043 | Nwi_0044 | Phosphopantothenate-cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.981 |
Nwi_0043 | mutM | Nwi_0043 | Nwi_0040 | Phosphopantothenate-cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | DNA-(apurinic or apyrimidinic site) lyase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.534 |
Nwi_0043 | ubiE | Nwi_0043 | Nwi_0041 | Phosphopantothenate-cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). | 0.680 |
Nwi_0045 | Nwi_0042 | Nwi_0045 | Nwi_0042 | Histidine kinase. | 2-octaprenylphenol hydroxylase. | 0.641 |
Nwi_0045 | Nwi_0043 | Nwi_0045 | Nwi_0043 | Histidine kinase. | Phosphopantothenate-cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.521 |
Nwi_0045 | Nwi_0046 | Nwi_0045 | Nwi_0046 | Histidine kinase. | Protein of unknown function UPF0079. | 0.866 |