node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Nwi_0052 | Nwi_1586 | Nwi_0052 | Nwi_1586 | Folylpolyglutamate synthetase; Belongs to the folylpolyglutamate synthase family. | Conserved hypothetical protein. | 0.566 |
Nwi_0052 | Nwi_2350 | Nwi_0052 | Nwi_2350 | Folylpolyglutamate synthetase; Belongs to the folylpolyglutamate synthase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.935 |
Nwi_0052 | folD | Nwi_0052 | Nwi_0480 | Folylpolyglutamate synthetase; Belongs to the folylpolyglutamate synthase family. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.561 |
Nwi_0052 | glyA | Nwi_0052 | Nwi_1727 | Folylpolyglutamate synthetase; Belongs to the folylpolyglutamate synthase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.740 |
Nwi_0052 | thyA | Nwi_0052 | Nwi_2351 | Folylpolyglutamate synthetase; Belongs to the folylpolyglutamate synthase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.871 |
Nwi_0284 | Nwi_1286 | Nwi_0284 | Nwi_1286 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system T protein. | 0.944 |
Nwi_0284 | folD | Nwi_0284 | Nwi_0480 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.943 |
Nwi_0284 | glyA | Nwi_0284 | Nwi_1727 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.954 |
Nwi_0284 | thyA | Nwi_0284 | Nwi_2351 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.936 |
Nwi_1286 | Nwi_0284 | Nwi_1286 | Nwi_0284 | Glycine cleavage system T protein. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.944 |
Nwi_1286 | Nwi_1586 | Nwi_1286 | Nwi_1586 | Glycine cleavage system T protein. | Conserved hypothetical protein. | 0.566 |
Nwi_1286 | Nwi_2350 | Nwi_1286 | Nwi_2350 | Glycine cleavage system T protein. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.913 |
Nwi_1286 | folD | Nwi_1286 | Nwi_0480 | Glycine cleavage system T protein. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.969 |
Nwi_1286 | glyA | Nwi_1286 | Nwi_1727 | Glycine cleavage system T protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.997 |
Nwi_1286 | thyA | Nwi_1286 | Nwi_2351 | Glycine cleavage system T protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.937 |
Nwi_1586 | Nwi_0052 | Nwi_1586 | Nwi_0052 | Conserved hypothetical protein. | Folylpolyglutamate synthetase; Belongs to the folylpolyglutamate synthase family. | 0.566 |
Nwi_1586 | Nwi_1286 | Nwi_1586 | Nwi_1286 | Conserved hypothetical protein. | Glycine cleavage system T protein. | 0.566 |
Nwi_1586 | thyA | Nwi_1586 | Nwi_2351 | Conserved hypothetical protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.887 |
Nwi_2350 | Nwi_0052 | Nwi_2350 | Nwi_0052 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Folylpolyglutamate synthetase; Belongs to the folylpolyglutamate synthase family. | 0.935 |
Nwi_2350 | Nwi_1286 | Nwi_2350 | Nwi_1286 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine cleavage system T protein. | 0.913 |