node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Noc_0137 | Noc_1604 | Noc_0137 | Noc_1604 | Protein of unknown function DUF28. | Glutamate synthase (NADH) large subunit. | 0.483 |
Noc_0137 | glnE | Noc_0137 | Noc_0135 | Protein of unknown function DUF28. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.591 |
Noc_0137 | ilvE | Noc_0137 | Noc_0136 | Protein of unknown function DUF28. | Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.665 |
Noc_0137 | nadE | Noc_0137 | Noc_2095 | Protein of unknown function DUF28. | NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.572 |
Noc_0715 | Noc_1604 | Noc_0715 | Noc_1604 | Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | Glutamate synthase (NADH) large subunit. | 0.847 |
Noc_0715 | Noc_2652 | Noc_0715 | Noc_2652 | Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | L-glutamine synthetase. | 0.659 |
Noc_0715 | argA | Noc_0715 | Noc_2013 | Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | N-acetylglutamate synthase; ArgA; Belongs to the acetyltransferase family. ArgA subfamily. | 0.867 |
Noc_0715 | glnD | Noc_0715 | Noc_0806 | Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | Protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. | 0.994 |
Noc_0715 | glnE | Noc_0715 | Noc_0135 | Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.565 |
Noc_0715 | nadE | Noc_0715 | Noc_2095 | Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.581 |
Noc_1301 | argA | Noc_1301 | Noc_2013 | ATP-dependent helicase HrpA. | N-acetylglutamate synthase; ArgA; Belongs to the acetyltransferase family. ArgA subfamily. | 0.485 |
Noc_1301 | glnE | Noc_1301 | Noc_0135 | ATP-dependent helicase HrpA. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.630 |
Noc_1604 | Noc_0137 | Noc_1604 | Noc_0137 | Glutamate synthase (NADH) large subunit. | Protein of unknown function DUF28. | 0.483 |
Noc_1604 | Noc_0715 | Noc_1604 | Noc_0715 | Glutamate synthase (NADH) large subunit. | Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | 0.847 |
Noc_1604 | Noc_2652 | Noc_1604 | Noc_2652 | Glutamate synthase (NADH) large subunit. | L-glutamine synthetase. | 0.996 |
Noc_1604 | argA | Noc_1604 | Noc_2013 | Glutamate synthase (NADH) large subunit. | N-acetylglutamate synthase; ArgA; Belongs to the acetyltransferase family. ArgA subfamily. | 0.847 |
Noc_1604 | glnD | Noc_1604 | Noc_0806 | Glutamate synthase (NADH) large subunit. | Protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. | 0.847 |
Noc_1604 | glnE | Noc_1604 | Noc_0135 | Glutamate synthase (NADH) large subunit. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.587 |
Noc_1604 | ilvE | Noc_1604 | Noc_0136 | Glutamate synthase (NADH) large subunit. | Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.447 |
Noc_2526 | glnE | Noc_2526 | Noc_0135 | Alkyl hydroperoxide reductase/ Thiol specific antioxidant. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.583 |