node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Noc_0503 | Noc_2574 | Noc_0503 | Noc_2574 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen synthase; Belongs to the ALAD family. | 0.958 |
Noc_0503 | cysG | Noc_0503 | Noc_0863 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Precorrin-2 dehydrogenase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.998 |
Noc_0503 | hemA | Noc_0503 | Noc_0510 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.869 |
Noc_0503 | hemC | Noc_0503 | Noc_0502 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.999 |
Noc_0503 | hemE | Noc_0503 | Noc_3008 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrinogen decarboxylase HemE; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.950 |
Noc_0503 | hemL | Noc_0503 | Noc_0600 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Glutamate-1-semialdehyde 2,1-aminomutase. | 0.764 |
Noc_0776 | hemL | Noc_0776 | Noc_0600 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. | Glutamate-1-semialdehyde 2,1-aminomutase. | 0.644 |
Noc_1666 | Noc_1956 | Noc_1666 | Noc_1956 | [Acyl-carrier-protein] S-malonyltransferase. | AMP-dependent synthetase and ligase. | 0.916 |
Noc_1666 | Noc_2574 | Noc_1666 | Noc_2574 | [Acyl-carrier-protein] S-malonyltransferase. | Porphobilinogen synthase; Belongs to the ALAD family. | 0.683 |
Noc_1666 | hemL | Noc_1666 | Noc_0600 | [Acyl-carrier-protein] S-malonyltransferase. | Glutamate-1-semialdehyde 2,1-aminomutase. | 0.571 |
Noc_1956 | Noc_1666 | Noc_1956 | Noc_1666 | AMP-dependent synthetase and ligase. | [Acyl-carrier-protein] S-malonyltransferase. | 0.916 |
Noc_1956 | hemL | Noc_1956 | Noc_0600 | AMP-dependent synthetase and ligase. | Glutamate-1-semialdehyde 2,1-aminomutase. | 0.910 |
Noc_2574 | Noc_0503 | Noc_2574 | Noc_0503 | Porphobilinogen synthase; Belongs to the ALAD family. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.958 |
Noc_2574 | Noc_1666 | Noc_2574 | Noc_1666 | Porphobilinogen synthase; Belongs to the ALAD family. | [Acyl-carrier-protein] S-malonyltransferase. | 0.683 |
Noc_2574 | cysG | Noc_2574 | Noc_0863 | Porphobilinogen synthase; Belongs to the ALAD family. | Precorrin-2 dehydrogenase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.950 |
Noc_2574 | hemA | Noc_2574 | Noc_0510 | Porphobilinogen synthase; Belongs to the ALAD family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.880 |
Noc_2574 | hemC | Noc_2574 | Noc_0502 | Porphobilinogen synthase; Belongs to the ALAD family. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.997 |
Noc_2574 | hemE | Noc_2574 | Noc_3008 | Porphobilinogen synthase; Belongs to the ALAD family. | Uroporphyrinogen decarboxylase HemE; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.804 |
Noc_2574 | hemL | Noc_2574 | Noc_0600 | Porphobilinogen synthase; Belongs to the ALAD family. | Glutamate-1-semialdehyde 2,1-aminomutase. | 0.996 |
cysG | Noc_0503 | Noc_0863 | Noc_0503 | Precorrin-2 dehydrogenase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.998 |