node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Noc_0291 | grpE | Noc_0291 | Noc_2812 | Hypothetical protein. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.932 |
Noc_0623 | Noc_1382 | Noc_0623 | Noc_1382 | Plasmid segregation actin-type ATPase ParM. | Heat shock protein DnaJ-like protein. | 0.962 |
Noc_0623 | dnaJ | Noc_0623 | Noc_2810 | Plasmid segregation actin-type ATPase ParM. | Heat shock protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.962 |
Noc_0623 | groL | Noc_0623 | Noc_2921 | Plasmid segregation actin-type ATPase ParM. | Chaperonin Cpn60/TCP-1; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.937 |
Noc_0623 | groS | Noc_0623 | Noc_2922 | Plasmid segregation actin-type ATPase ParM. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.869 |
Noc_0623 | grpE | Noc_0623 | Noc_2812 | Plasmid segregation actin-type ATPase ParM. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.970 |
Noc_0623 | hrcA | Noc_0623 | Noc_2813 | Plasmid segregation actin-type ATPase ParM. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.832 |
Noc_0623 | hslU | Noc_0623 | Noc_2341 | Plasmid segregation actin-type ATPase ParM. | Heat shock protein HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.672 |
Noc_0667 | Noc_1382 | Noc_0667 | Noc_1382 | Heat shock protein Hsp70. | Heat shock protein DnaJ-like protein. | 0.976 |
Noc_0667 | dnaJ | Noc_0667 | Noc_2810 | Heat shock protein Hsp70. | Heat shock protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.996 |
Noc_0667 | dnaK | Noc_0667 | Noc_2811 | Heat shock protein Hsp70. | Heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.927 |
Noc_0667 | groL | Noc_0667 | Noc_2921 | Heat shock protein Hsp70. | Chaperonin Cpn60/TCP-1; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.961 |
Noc_0667 | groS | Noc_0667 | Noc_2922 | Heat shock protein Hsp70. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.891 |
Noc_0667 | grpE | Noc_0667 | Noc_2812 | Heat shock protein Hsp70. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.992 |
Noc_0667 | hrcA | Noc_0667 | Noc_2813 | Heat shock protein Hsp70. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.857 |
Noc_0667 | hslU | Noc_0667 | Noc_2341 | Heat shock protein Hsp70. | Heat shock protein HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.808 |
Noc_1382 | Noc_0623 | Noc_1382 | Noc_0623 | Heat shock protein DnaJ-like protein. | Plasmid segregation actin-type ATPase ParM. | 0.962 |
Noc_1382 | Noc_0667 | Noc_1382 | Noc_0667 | Heat shock protein DnaJ-like protein. | Heat shock protein Hsp70. | 0.976 |
Noc_1382 | dnaK | Noc_1382 | Noc_2811 | Heat shock protein DnaJ-like protein. | Heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.993 |
Noc_1382 | groL | Noc_1382 | Noc_2921 | Heat shock protein DnaJ-like protein. | Chaperonin Cpn60/TCP-1; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.878 |