STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gcvPAGlycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (452 aa)    
Predicted Functional Partners:
gcvPB
Glycine dehydrogenase (decarboxylating) beta subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily.
0.999
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 0.999
gcvT
Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.
 
 0.999
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
 
 
 0.970
ABB73823.1
Dihydrolipoamide dehydrogenase.
  
 
 0.946
ABB74158.1
Dihydrolipoamide dehydrogenase.
  
 
 0.916
ABB75369.1
D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein.
  
 
 0.916
ABB75827.1
Alanine-glyoxylate aminotransferase apoenzyme.
     
 0.900
ABB75580.1
L-glutamine synthetase.
   
 
 0.834
ABB75736.1
Glutamate dehydrogenase (NADP); Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 
 0.803
Your Current Organism:
Nitrosospira multiformis
NCBI taxonomy Id: 323848
Other names: N. multiformis ATCC 25196, Nitrosospira multiformis ATCC 25196, Nitrosospira multiformis C-71, Nitrosospira multiformis NCIMB 11849, Nitrosospira multiformis NI13, Nitrosospira multiformis str. ATCC 25196, Nitrosospira multiformis strain ATCC 25196
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.