node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Shew_0966 | Shew_1720 | Shew_0966 | Shew_1720 | PFAM: aminotransferase class-III; KEGG: she:Shewmr4_2927 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 8-amino-7-oxononanoate synthase; PFAM: aminotransferase, class I and II; aminotransferase class-III; KEGG: son:SO2739 8-amino-7-oxononanoate synthase. | 0.535 |
Shew_0966 | Shew_3218 | Shew_0966 | Shew_3218 | PFAM: aminotransferase class-III; KEGG: she:Shewmr4_2927 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | PFAM: biotin/lipoyl attachment domain-containing protein; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; KEGG: she:Shewmr4_0696 carbamoyl-phosphate synthase L chain, ATP-binding. | 0.486 |
Shew_0966 | bioB | Shew_0966 | Shew_1719 | PFAM: aminotransferase class-III; KEGG: she:Shewmr4_2927 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.777 |
Shew_0966 | bioD | Shew_0966 | Shew_1722 | PFAM: aminotransferase class-III; KEGG: she:Shewmr4_2927 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.764 |
Shew_0966 | birA | Shew_0966 | Shew_0142 | PFAM: aminotransferase class-III; KEGG: she:Shewmr4_2927 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.494 |
Shew_0966 | kbl | Shew_0966 | Shew_3709 | PFAM: aminotransferase class-III; KEGG: she:Shewmr4_2927 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.529 |
Shew_1718 | Shew_1720 | Shew_1718 | Shew_1720 | Aminotransferase; TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: aminotransferase class-III; KEGG: shm:Shewmr7_2432 adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 8-amino-7-oxononanoate synthase; PFAM: aminotransferase, class I and II; aminotransferase class-III; KEGG: son:SO2739 8-amino-7-oxononanoate synthase. | 0.990 |
Shew_1718 | Shew_1721 | Shew_1718 | Shew_1721 | Aminotransferase; TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: aminotransferase class-III; KEGG: shm:Shewmr7_2432 adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: she:Shewmr4_2357 biotin biosynthesis protein BioC. | 0.688 |
Shew_1718 | Shew_3218 | Shew_1718 | Shew_3218 | Aminotransferase; TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: aminotransferase class-III; KEGG: shm:Shewmr7_2432 adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | PFAM: biotin/lipoyl attachment domain-containing protein; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; KEGG: she:Shewmr4_0696 carbamoyl-phosphate synthase L chain, ATP-binding. | 0.486 |
Shew_1718 | bioB | Shew_1718 | Shew_1719 | Aminotransferase; TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: aminotransferase class-III; KEGG: shm:Shewmr7_2432 adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.980 |
Shew_1718 | bioD | Shew_1718 | Shew_1722 | Aminotransferase; TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: aminotransferase class-III; KEGG: shm:Shewmr7_2432 adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.996 |
Shew_1718 | birA | Shew_1718 | Shew_0142 | Aminotransferase; TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: aminotransferase class-III; KEGG: shm:Shewmr7_2432 adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.494 |
Shew_1718 | kbl | Shew_1718 | Shew_3709 | Aminotransferase; TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: aminotransferase class-III; KEGG: shm:Shewmr7_2432 adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.609 |
Shew_1720 | Shew_0966 | Shew_1720 | Shew_0966 | 8-amino-7-oxononanoate synthase; PFAM: aminotransferase, class I and II; aminotransferase class-III; KEGG: son:SO2739 8-amino-7-oxononanoate synthase. | PFAM: aminotransferase class-III; KEGG: she:Shewmr4_2927 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.535 |
Shew_1720 | Shew_1718 | Shew_1720 | Shew_1718 | 8-amino-7-oxononanoate synthase; PFAM: aminotransferase, class I and II; aminotransferase class-III; KEGG: son:SO2739 8-amino-7-oxononanoate synthase. | Aminotransferase; TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: aminotransferase class-III; KEGG: shm:Shewmr7_2432 adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.990 |
Shew_1720 | Shew_1721 | Shew_1720 | Shew_1721 | 8-amino-7-oxononanoate synthase; PFAM: aminotransferase, class I and II; aminotransferase class-III; KEGG: son:SO2739 8-amino-7-oxononanoate synthase. | PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: she:Shewmr4_2357 biotin biosynthesis protein BioC. | 0.890 |
Shew_1720 | Shew_3218 | Shew_1720 | Shew_3218 | 8-amino-7-oxononanoate synthase; PFAM: aminotransferase, class I and II; aminotransferase class-III; KEGG: son:SO2739 8-amino-7-oxononanoate synthase. | PFAM: biotin/lipoyl attachment domain-containing protein; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; KEGG: she:Shewmr4_0696 carbamoyl-phosphate synthase L chain, ATP-binding. | 0.519 |
Shew_1720 | bioB | Shew_1720 | Shew_1719 | 8-amino-7-oxononanoate synthase; PFAM: aminotransferase, class I and II; aminotransferase class-III; KEGG: son:SO2739 8-amino-7-oxononanoate synthase. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.943 |
Shew_1720 | bioD | Shew_1720 | Shew_1722 | 8-amino-7-oxononanoate synthase; PFAM: aminotransferase, class I and II; aminotransferase class-III; KEGG: son:SO2739 8-amino-7-oxononanoate synthase. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.968 |
Shew_1720 | birA | Shew_1720 | Shew_0142 | 8-amino-7-oxononanoate synthase; PFAM: aminotransferase, class I and II; aminotransferase class-III; KEGG: son:SO2739 8-amino-7-oxononanoate synthase. | biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.500 |