node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Shew_0128 | Shew_0363 | Shew_0128 | Shew_0363 | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: shm:Shewmr7_0162 HAD-superfamily hydrolase, subfamily IA, variant 3. | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: yps:YPTB2218 haloacid dehalogenase-like hydrolase family protein. | 0.915 |
Shew_0128 | Shew_3055 | Shew_0128 | Shew_3055 | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: shm:Shewmr7_0162 HAD-superfamily hydrolase, subfamily IA, variant 3. | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: sfr:Sfri_3571 CMP/dCMP deaminase, zinc-binding. | 0.908 |
Shew_0128 | dut | Shew_0128 | Shew_3483 | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: shm:Shewmr7_0162 HAD-superfamily hydrolase, subfamily IA, variant 3. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.901 |
Shew_0128 | tdk | Shew_0128 | Shew_2579 | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: shm:Shewmr7_0162 HAD-superfamily hydrolase, subfamily IA, variant 3. | PFAM: thymidine kinase; KEGG: sdn:Sden_2536 thymidine kinase. | 0.902 |
Shew_0128 | thyA | Shew_0128 | Shew_1041 | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: shm:Shewmr7_0162 HAD-superfamily hydrolase, subfamily IA, variant 3. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.903 |
Shew_0128 | tmk | Shew_0128 | Shew_1579 | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: shm:Shewmr7_0162 HAD-superfamily hydrolase, subfamily IA, variant 3. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.901 |
Shew_0363 | Shew_0128 | Shew_0363 | Shew_0128 | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: yps:YPTB2218 haloacid dehalogenase-like hydrolase family protein. | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: shm:Shewmr7_0162 HAD-superfamily hydrolase, subfamily IA, variant 3. | 0.915 |
Shew_0363 | Shew_3055 | Shew_0363 | Shew_3055 | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: yps:YPTB2218 haloacid dehalogenase-like hydrolase family protein. | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: sfr:Sfri_3571 CMP/dCMP deaminase, zinc-binding. | 0.908 |
Shew_0363 | dut | Shew_0363 | Shew_3483 | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: yps:YPTB2218 haloacid dehalogenase-like hydrolase family protein. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.901 |
Shew_0363 | tdk | Shew_0363 | Shew_2579 | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: yps:YPTB2218 haloacid dehalogenase-like hydrolase family protein. | PFAM: thymidine kinase; KEGG: sdn:Sden_2536 thymidine kinase. | 0.914 |
Shew_0363 | thyA | Shew_0363 | Shew_1041 | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: yps:YPTB2218 haloacid dehalogenase-like hydrolase family protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.903 |
Shew_0363 | tmk | Shew_0363 | Shew_1579 | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: yps:YPTB2218 haloacid dehalogenase-like hydrolase family protein. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.901 |
Shew_2449 | dcd | Shew_2449 | Shew_1576 | KEGG: she:Shewmr4_2441 anaerobic ribonucleoside-triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: formate C-acetyltransferase glycine radical; ATP-cone domain protein. | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.905 |
Shew_2449 | dut | Shew_2449 | Shew_3483 | KEGG: she:Shewmr4_2441 anaerobic ribonucleoside-triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: formate C-acetyltransferase glycine radical; ATP-cone domain protein. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.925 |
Shew_2449 | ndk | Shew_2449 | Shew_2310 | KEGG: she:Shewmr4_2441 anaerobic ribonucleoside-triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: formate C-acetyltransferase glycine radical; ATP-cone domain protein. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.913 |
Shew_3055 | Shew_0128 | Shew_3055 | Shew_0128 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: sfr:Sfri_3571 CMP/dCMP deaminase, zinc-binding. | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: shm:Shewmr7_0162 HAD-superfamily hydrolase, subfamily IA, variant 3. | 0.908 |
Shew_3055 | Shew_0363 | Shew_3055 | Shew_0363 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: sfr:Sfri_3571 CMP/dCMP deaminase, zinc-binding. | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: yps:YPTB2218 haloacid dehalogenase-like hydrolase family protein. | 0.908 |
Shew_3055 | dut | Shew_3055 | Shew_3483 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: sfr:Sfri_3571 CMP/dCMP deaminase, zinc-binding. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.946 |
Shew_3055 | tdk | Shew_3055 | Shew_2579 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: sfr:Sfri_3571 CMP/dCMP deaminase, zinc-binding. | PFAM: thymidine kinase; KEGG: sdn:Sden_2536 thymidine kinase. | 0.931 |
Shew_3055 | thyA | Shew_3055 | Shew_1041 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: sfr:Sfri_3571 CMP/dCMP deaminase, zinc-binding. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.941 |