STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
Caur_13514-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. (343 aa)    
Predicted Functional Partners:
Caur_1350
Acetaldehyde dehydrogenase (acetylating); Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.
 0.999
Caur_1357
PFAM: Hydratase/decarboxylase; KEGG: rrs:RoseRS_2578 4-oxalocrotonate decarboxylase.
 
 
 0.989
Caur_1355
PFAM: Hydratase/decarboxylase; KEGG: rrs:RoseRS_2576 hydratase/decarboxylase.
 
  
 0.898
Caur_1354
TIGRFAM: 4-oxalocrotonate tautomerase family enzyme; PFAM: 4-oxalocrotonate tautomerase; KEGG: rrs:RoseRS_2575 4-oxalocrotonate tautomerase family enzyme.
 
   
 0.896
Caur_1353
PFAM: alpha/beta hydrolase fold; KEGG: ttj:TTHB237 2-hydroxymuconic semialdehyde hydrolase.
 
    0.887
Caur_1348
Catechol 2,3 dioxygenase; KEGG: ttj:TTHB250 metapyrocatechase (catechol 2,3-dioxygenase); TIGRFAM: catechol 2,3 dioxygenase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase.
 
   
 0.864
Caur_1349
PFAM: regulatory protein IclR; Transcriptional regulator IclR; KEGG: rrs:RoseRS_2571 regulatory protein, IclR.
 
     0.863
Caur_1352
PFAM: flavin reductase domain protein FMN-binding; KEGG: rca:Rcas_2409 flavin reductase domain protein FMN-binding.
     
 0.827
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
  
 0.795
ilvD
KEGG: tel:tll1057 dihydroxyacid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family.
  
  
 0.748
Your Current Organism:
Chloroflexus aurantiacus
NCBI taxonomy Id: 324602
Other names: C. aurantiacus J-10-fl, Chloroflexus aurantiacus ATCC 29366, Chloroflexus aurantiacus DSM 635, Chloroflexus aurantiacus J-10-fl, Chloroflexus aurantiacus str. J-10-fl, Chloroflexus aurantiacus strain J-10-fl
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