node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Caur_0500 | mtnP | Caur_0500 | Caur_3616 | TIGRFAM: 6-phosphogluconate dehydrogenase, decarboxylating; PFAM: NADP oxidoreductase coenzyme F420-dependent; 6-phosphogluconate dehydrogenase domain protein; 6-phosphogluconate dehydrogenase NAD-binding; KEGG: rrs:RoseRS_4286 6-phosphogluconate dehydrogenase, decarboxylating. | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 0.434 |
Caur_3613 | Caur_3614 | Caur_3613 | Caur_3614 | PFAM: TrkA-N domain protein; TrkA-C domain protein; sodium/hydrogen exchanger; KEGG: rca:Rcas_4297 TrkA-C domain protein; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. | PFAM: nitroreductase; KEGG: rrs:RoseRS_1137 nitroreductase. | 0.515 |
Caur_3613 | Caur_3615 | Caur_3613 | Caur_3615 | PFAM: TrkA-N domain protein; TrkA-C domain protein; sodium/hydrogen exchanger; KEGG: rca:Rcas_4297 TrkA-C domain protein; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. | TIGRFAM: F420-dependent oxidoreductase; PFAM: protein of unknown function DUF129; KEGG: rrs:RoseRS_1136 F420-dependent oxidoreductase, putative. | 0.436 |
Caur_3613 | guaB | Caur_3613 | Caur_0616 | PFAM: TrkA-N domain protein; TrkA-C domain protein; sodium/hydrogen exchanger; KEGG: rca:Rcas_4297 TrkA-C domain protein; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.546 |
Caur_3613 | mtnP | Caur_3613 | Caur_3616 | PFAM: TrkA-N domain protein; TrkA-C domain protein; sodium/hydrogen exchanger; KEGG: rca:Rcas_4297 TrkA-C domain protein; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 0.449 |
Caur_3614 | Caur_3613 | Caur_3614 | Caur_3613 | PFAM: nitroreductase; KEGG: rrs:RoseRS_1137 nitroreductase. | PFAM: TrkA-N domain protein; TrkA-C domain protein; sodium/hydrogen exchanger; KEGG: rca:Rcas_4297 TrkA-C domain protein; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. | 0.515 |
Caur_3614 | Caur_3615 | Caur_3614 | Caur_3615 | PFAM: nitroreductase; KEGG: rrs:RoseRS_1137 nitroreductase. | TIGRFAM: F420-dependent oxidoreductase; PFAM: protein of unknown function DUF129; KEGG: rrs:RoseRS_1136 F420-dependent oxidoreductase, putative. | 0.985 |
Caur_3614 | mtnP | Caur_3614 | Caur_3616 | PFAM: nitroreductase; KEGG: rrs:RoseRS_1137 nitroreductase. | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 0.773 |
Caur_3615 | Caur_3613 | Caur_3615 | Caur_3613 | TIGRFAM: F420-dependent oxidoreductase; PFAM: protein of unknown function DUF129; KEGG: rrs:RoseRS_1136 F420-dependent oxidoreductase, putative. | PFAM: TrkA-N domain protein; TrkA-C domain protein; sodium/hydrogen exchanger; KEGG: rca:Rcas_4297 TrkA-C domain protein; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. | 0.436 |
Caur_3615 | Caur_3614 | Caur_3615 | Caur_3614 | TIGRFAM: F420-dependent oxidoreductase; PFAM: protein of unknown function DUF129; KEGG: rrs:RoseRS_1136 F420-dependent oxidoreductase, putative. | PFAM: nitroreductase; KEGG: rrs:RoseRS_1137 nitroreductase. | 0.985 |
Caur_3615 | mtnP | Caur_3615 | Caur_3616 | TIGRFAM: F420-dependent oxidoreductase; PFAM: protein of unknown function DUF129; KEGG: rrs:RoseRS_1136 F420-dependent oxidoreductase, putative. | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 0.825 |
Caur_3631 | mtnA | Caur_3631 | Caur_3025 | PFAM: MaoC domain protein dehydratase; KEGG: mmw:Mmwyl1_2239 MaoC domain protein dehydratase. | Translation initiation factor, aIF-2BI family; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.453 |
Caur_3631 | mtnP | Caur_3631 | Caur_3616 | PFAM: MaoC domain protein dehydratase; KEGG: mmw:Mmwyl1_2239 MaoC domain protein dehydratase. | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 0.495 |
apt | guaA | Caur_0273 | Caur_0973 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.991 |
apt | guaB | Caur_0273 | Caur_0616 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.607 |
apt | mtnA | Caur_0273 | Caur_3025 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Translation initiation factor, aIF-2BI family; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.819 |
apt | mtnP | Caur_0273 | Caur_3616 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 0.946 |
guaA | apt | Caur_0973 | Caur_0273 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.991 |
guaA | guaB | Caur_0973 | Caur_0616 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
guaA | mtnP | Caur_0973 | Caur_3616 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 0.603 |