STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSXCOP00000005226E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (185 aa)    
Predicted Functional Partners:
ENSXCOP00000017057
Thyroid hormone receptor interactor 12.
   
 0.977
ENSXCOP00000005233
E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
 
      0.899
UBR1
E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
 
      0.899
LOC114138068
Ribosomal protein S27a.
   
 0.642
Eftud2
Elongation factor Tu GTP binding domain containing 2.
      
 0.639
ENSXCOP00000005305
Ubiquitin-conjugating enzyme E2B (RAD6 homolog).
   
 
 0.638
ube2a
Ubiquitin-conjugating enzyme E2A (RAD6 homolog); Belongs to the ubiquitin-conjugating enzyme family.
   
 
 0.638
LOC114148726
Ubiquitin conjugating enzyme E2 A, like; Belongs to the ubiquitin-conjugating enzyme family.
   
 
 0.638
LTN1
Listerin E3 ubiquitin protein ligase 1.
   
 0.510
ENSXCOP00000011612
Myb-like, SWIRM and MPN domains 1.
   
  
 0.466
Your Current Organism:
Xiphophorus couchianus
NCBI taxonomy Id: 32473
Other names: Limia couchiana, Monterrey platyfish, X. couchianus
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