node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Sbal_2390 | Sbal_2392 | Sbal_2390 | Sbal_2392 | PFAM: protein of unknown function DUF528; KEGG: shn:Shewana3_2273 protein of unknown function DUF528. | TIGRFAM: ferredoxin, 2Fe-2S type, ISC system; PFAM: ferredoxin; KEGG: shn:Shewana3_2275 ferredoxin, 2Fe-2S type, ISC system. | 0.985 |
Sbal_2390 | Sbal_2395 | Sbal_2390 | Sbal_2395 | PFAM: protein of unknown function DUF528; KEGG: shn:Shewana3_2273 protein of unknown function DUF528. | Iron-sulfur cluster assembly protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. | 0.818 |
Sbal_2390 | Sbal_2396 | Sbal_2390 | Sbal_2396 | PFAM: protein of unknown function DUF528; KEGG: shn:Shewana3_2273 protein of unknown function DUF528. | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.927 |
Sbal_2390 | Sbal_2398 | Sbal_2390 | Sbal_2398 | PFAM: protein of unknown function DUF528; KEGG: shn:Shewana3_2273 protein of unknown function DUF528. | Transcriptional regulator, BadM/Rrf2 family; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | 0.484 |
Sbal_2390 | cyaY | Sbal_2390 | Sbal_3998 | PFAM: protein of unknown function DUF528; KEGG: shn:Shewana3_2273 protein of unknown function DUF528. | Frataxin family protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | 0.638 |
Sbal_2390 | dnaK | Sbal_2390 | Sbal_3319 | PFAM: protein of unknown function DUF528; KEGG: shn:Shewana3_2273 protein of unknown function DUF528. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.606 |
Sbal_2390 | hscA | Sbal_2390 | Sbal_2393 | PFAM: protein of unknown function DUF528; KEGG: shn:Shewana3_2273 protein of unknown function DUF528. | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. | 0.893 |
Sbal_2390 | hscB | Sbal_2390 | Sbal_2394 | PFAM: protein of unknown function DUF528; KEGG: shn:Shewana3_2273 protein of unknown function DUF528. | Co-chaperone Hsc20; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.976 |
Sbal_2390 | iscS | Sbal_2390 | Sbal_2397 | PFAM: protein of unknown function DUF528; KEGG: shn:Shewana3_2273 protein of unknown function DUF528. | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.900 |
Sbal_2390 | nfuA | Sbal_2390 | Sbal_0142 | PFAM: protein of unknown function DUF528; KEGG: shn:Shewana3_2273 protein of unknown function DUF528. | HesB/YadR/YfhF-family protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.745 |
Sbal_2392 | Sbal_2390 | Sbal_2392 | Sbal_2390 | TIGRFAM: ferredoxin, 2Fe-2S type, ISC system; PFAM: ferredoxin; KEGG: shn:Shewana3_2275 ferredoxin, 2Fe-2S type, ISC system. | PFAM: protein of unknown function DUF528; KEGG: shn:Shewana3_2273 protein of unknown function DUF528. | 0.985 |
Sbal_2392 | Sbal_2395 | Sbal_2392 | Sbal_2395 | TIGRFAM: ferredoxin, 2Fe-2S type, ISC system; PFAM: ferredoxin; KEGG: shn:Shewana3_2275 ferredoxin, 2Fe-2S type, ISC system. | Iron-sulfur cluster assembly protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. | 0.981 |
Sbal_2392 | Sbal_2396 | Sbal_2392 | Sbal_2396 | TIGRFAM: ferredoxin, 2Fe-2S type, ISC system; PFAM: ferredoxin; KEGG: shn:Shewana3_2275 ferredoxin, 2Fe-2S type, ISC system. | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.997 |
Sbal_2392 | Sbal_2398 | Sbal_2392 | Sbal_2398 | TIGRFAM: ferredoxin, 2Fe-2S type, ISC system; PFAM: ferredoxin; KEGG: shn:Shewana3_2275 ferredoxin, 2Fe-2S type, ISC system. | Transcriptional regulator, BadM/Rrf2 family; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | 0.707 |
Sbal_2392 | cyaY | Sbal_2392 | Sbal_3998 | TIGRFAM: ferredoxin, 2Fe-2S type, ISC system; PFAM: ferredoxin; KEGG: shn:Shewana3_2275 ferredoxin, 2Fe-2S type, ISC system. | Frataxin family protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | 0.905 |
Sbal_2392 | dnaK | Sbal_2392 | Sbal_3319 | TIGRFAM: ferredoxin, 2Fe-2S type, ISC system; PFAM: ferredoxin; KEGG: shn:Shewana3_2275 ferredoxin, 2Fe-2S type, ISC system. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.761 |
Sbal_2392 | hscA | Sbal_2392 | Sbal_2393 | TIGRFAM: ferredoxin, 2Fe-2S type, ISC system; PFAM: ferredoxin; KEGG: shn:Shewana3_2275 ferredoxin, 2Fe-2S type, ISC system. | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. | 0.985 |
Sbal_2392 | hscB | Sbal_2392 | Sbal_2394 | TIGRFAM: ferredoxin, 2Fe-2S type, ISC system; PFAM: ferredoxin; KEGG: shn:Shewana3_2275 ferredoxin, 2Fe-2S type, ISC system. | Co-chaperone Hsc20; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.991 |
Sbal_2392 | iscS | Sbal_2392 | Sbal_2397 | TIGRFAM: ferredoxin, 2Fe-2S type, ISC system; PFAM: ferredoxin; KEGG: shn:Shewana3_2275 ferredoxin, 2Fe-2S type, ISC system. | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.992 |
Sbal_2392 | nfuA | Sbal_2392 | Sbal_0142 | TIGRFAM: ferredoxin, 2Fe-2S type, ISC system; PFAM: ferredoxin; KEGG: shn:Shewana3_2275 ferredoxin, 2Fe-2S type, ISC system. | HesB/YadR/YfhF-family protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.671 |