STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mdhMalate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. (311 aa)    
Predicted Functional Partners:
Sama_1688
Fumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
 
 0.997
Sama_1422
KEGG: son:SO1926 citrate synthase; Belongs to the citrate synthase family.
  
 0.981
fumC
Fumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 0.971
Sama_2059
KEGG: son:SO2629 isocitrate dehydrogenase, NADP-dependent; Belongs to the monomeric-type IDH family.
  
  
 0.956
Sama_1052
KEGG: vvy:VV2799 oxaloacetate decarboxylase, alpha subunit.
    
 0.947
pckA
Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
  
 
 0.936
ppc
Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family.
     
 0.933
Sama_0448
KEGG: sdn:Sden_3353 malate dehydrogenase (oxaloacetate decarboxylating) (NADP+).
  
 0.931
maeA
Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)); KEGG: son:SO3855 malate oxidoreductase; Belongs to the malic enzymes family.
  
 0.931
Sama_3295
KEGG: son:SO0344 methylcitrate synthase; Belongs to the citrate synthase family.
  
 0.930
Your Current Organism:
Shewanella amazonensis
NCBI taxonomy Id: 326297
Other names: S. amazonensis SB2B, Shewanella amazonensis SB2B, Shewanella amazonensis str. SB2B, Shewanella amazonensis strain SB2B
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