node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Sama_1439 | Sama_1440 | Sama_1439 | Sama_1440 | KEGG: she:Shewmr4_2358 8-amino-7-oxononanoate synthase. | KEGG: son:SO2738 biotin synthesis protein BioC. | 0.937 |
Sama_1439 | Sama_2643 | Sama_1439 | Sama_2643 | KEGG: she:Shewmr4_2358 8-amino-7-oxononanoate synthase. | Aminotransferase; KEGG: cps:CPS_4663 aminotransferase, class III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.439 |
Sama_1439 | Sama_2649 | Sama_1439 | Sama_2649 | KEGG: she:Shewmr4_2358 8-amino-7-oxononanoate synthase. | Aminotransferase; KEGG: son:SO3497 aminotransferase, class III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.439 |
Sama_1439 | Sama_3606 | Sama_1439 | Sama_3606 | KEGG: she:Shewmr4_2358 8-amino-7-oxononanoate synthase. | Aminotransferase; KEGG: bcz:BCZK0297 aminotransferase, class III; probable 4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.421 |
Sama_1439 | bioA | Sama_1439 | Sama_1437 | KEGG: she:Shewmr4_2358 8-amino-7-oxononanoate synthase. | Aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 0.991 |
Sama_1439 | bioB | Sama_1439 | Sama_1438 | KEGG: she:Shewmr4_2358 8-amino-7-oxononanoate synthase. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.951 |
Sama_1439 | bioD | Sama_1439 | Sama_1441 | KEGG: she:Shewmr4_2358 8-amino-7-oxononanoate synthase. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.985 |
Sama_1439 | birA | Sama_1439 | Sama_0197 | KEGG: she:Shewmr4_2358 8-amino-7-oxononanoate synthase. | Biotin--(acetyl-CoA-carboxylase) ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.506 |
Sama_1440 | Sama_1439 | Sama_1440 | Sama_1439 | KEGG: son:SO2738 biotin synthesis protein BioC. | KEGG: she:Shewmr4_2358 8-amino-7-oxononanoate synthase. | 0.937 |
Sama_1440 | bioA | Sama_1440 | Sama_1437 | KEGG: son:SO2738 biotin synthesis protein BioC. | Aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 0.715 |
Sama_1440 | bioB | Sama_1440 | Sama_1438 | KEGG: son:SO2738 biotin synthesis protein BioC. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.964 |
Sama_1440 | bioD | Sama_1440 | Sama_1441 | KEGG: son:SO2738 biotin synthesis protein BioC. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.971 |
Sama_1440 | kbl | Sama_1440 | Sama_0098 | KEGG: son:SO2738 biotin synthesis protein BioC. | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.688 |
Sama_2643 | Sama_1439 | Sama_2643 | Sama_1439 | Aminotransferase; KEGG: cps:CPS_4663 aminotransferase, class III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | KEGG: she:Shewmr4_2358 8-amino-7-oxononanoate synthase. | 0.439 |
Sama_2643 | bioB | Sama_2643 | Sama_1438 | Aminotransferase; KEGG: cps:CPS_4663 aminotransferase, class III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.638 |
Sama_2643 | bioD | Sama_2643 | Sama_1441 | Aminotransferase; KEGG: cps:CPS_4663 aminotransferase, class III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.615 |
Sama_2643 | birA | Sama_2643 | Sama_0197 | Aminotransferase; KEGG: cps:CPS_4663 aminotransferase, class III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Biotin--(acetyl-CoA-carboxylase) ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.489 |
Sama_2643 | kbl | Sama_2643 | Sama_0098 | Aminotransferase; KEGG: cps:CPS_4663 aminotransferase, class III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.429 |
Sama_2649 | Sama_1439 | Sama_2649 | Sama_1439 | Aminotransferase; KEGG: son:SO3497 aminotransferase, class III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | KEGG: she:Shewmr4_2358 8-amino-7-oxononanoate synthase. | 0.439 |
Sama_2649 | Sama_3606 | Sama_2649 | Sama_3606 | Aminotransferase; KEGG: son:SO3497 aminotransferase, class III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Aminotransferase; KEGG: bcz:BCZK0297 aminotransferase, class III; probable 4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.924 |