STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (664 aa)    
Predicted Functional Partners:
thiE
Phosphomethylpyrimidine kinase., Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
 0.999
thiG
Thiazole biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
  
 0.993
Sama_1855
KEGG: son:SO2440 thiH protein.
 
  
 0.984
Sama_1857
KEGG: sdn:Sden_1773 thiamine biosynthesis protein ThiS.
  
  
 0.959
Sama_1858
KEGG: son:SO2443 thiF protein, putative.
 
  
 0.921
purM
KEGG: son:SO2760 phosphoribosylformylglycinamidine cyclo-ligase.
     
 0.807
purK
Phosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Belongs to the PurK/PurT family.
     
  0.800
Sama_3556
KEGG: son:SO4661 hypothetical protein.
  
  
 0.690
Sama_3561
KEGG: son:SO4661 hypothetical protein.
  
  
 0.690
Sama_0137
[molybdopterin synthase] sulfurylase; KEGG: son:SO0137 molybdopterin biosynthesis MoeB protein.
 
  
 0.654
Your Current Organism:
Shewanella amazonensis
NCBI taxonomy Id: 326297
Other names: S. amazonensis SB2B, Shewanella amazonensis SB2B, Shewanella amazonensis str. SB2B, Shewanella amazonensis strain SB2B
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