node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Sama_0978 | hisA | Sama_0978 | Sama_1946 | KEGG: son:SO1223 phosphoserine phosphatase. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: sdn:Sden_1613 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.725 |
Sama_0978 | hisB | Sama_0978 | Sama_1944 | KEGG: son:SO1223 phosphoserine phosphatase. | KEGG: son:SO2071 histidinol-phosphatase / imidazoleglycerol-phosphate dehydratase; In the N-terminal section; belongs to the histidinol- phosphatase family. | 0.809 |
Sama_0978 | hisC | Sama_0978 | Sama_1943 | KEGG: son:SO1223 phosphoserine phosphatase. | KEGG: son:SO2072 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.612 |
Sama_0978 | hisD | Sama_0978 | Sama_1942 | KEGG: son:SO1223 phosphoserine phosphatase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.643 |
Sama_0978 | hisF | Sama_0978 | Sama_1947 | KEGG: son:SO1223 phosphoserine phosphatase. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.792 |
Sama_0978 | hisG | Sama_0978 | Sama_1941 | KEGG: son:SO1223 phosphoserine phosphatase. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.495 |
Sama_0978 | hisH | Sama_0978 | Sama_1945 | KEGG: son:SO1223 phosphoserine phosphatase. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.721 |
Sama_0978 | hisI | Sama_0978 | Sama_1948 | KEGG: son:SO1223 phosphoserine phosphatase. | phosphoribosyl-ATP pyrophosphatase / phosphoribosyl-AMP cyclohydrolase; KEGG: son:SO2067 phosphoribosyl-AMP cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.980 |
guaA | hisA | Sama_2358 | Sama_1946 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: sdn:Sden_1613 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.773 |
guaA | hisF | Sama_2358 | Sama_1947 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.497 |
guaA | hisH | Sama_2358 | Sama_1945 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.501 |
guaA | trpF | Sama_2358 | Sama_2132 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | KEGG: son:SO3022 indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Belongs to the TrpC family. | 0.612 |
hisA | Sama_0978 | Sama_1946 | Sama_0978 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: sdn:Sden_1613 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | KEGG: son:SO1223 phosphoserine phosphatase. | 0.725 |
hisA | guaA | Sama_1946 | Sama_2358 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: sdn:Sden_1613 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.773 |
hisA | hisB | Sama_1946 | Sama_1944 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: sdn:Sden_1613 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | KEGG: son:SO2071 histidinol-phosphatase / imidazoleglycerol-phosphate dehydratase; In the N-terminal section; belongs to the histidinol- phosphatase family. | 0.999 |
hisA | hisC | Sama_1946 | Sama_1943 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: sdn:Sden_1613 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | KEGG: son:SO2072 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.996 |
hisA | hisD | Sama_1946 | Sama_1942 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: sdn:Sden_1613 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.996 |
hisA | hisF | Sama_1946 | Sama_1947 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: sdn:Sden_1613 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | Sama_1946 | Sama_1941 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: sdn:Sden_1613 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.996 |
hisA | hisH | Sama_1946 | Sama_1945 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: sdn:Sden_1613 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |