node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
guaA | guaB | Sama_2358 | Sama_2359 | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | 0.999 |
guaA | purC | Sama_2358 | Sama_0491 | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family | 0.946 |
guaA | purD | Sama_2358 | Sama_0394 | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | Phosphoribosylamine---glycine ligase; Belongs to the GARS family | 0.979 |
guaA | purE | Sama_2358 | Sama_1064 | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | 5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) | 0.945 |
guaA | purF | Sama_2358 | Sama_2146 | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine | 0.965 |
guaA | purH | Sama_2358 | Sama_0395 | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | Phosphoribosylaminoimidazolecarboxamide formyltransferase / imp cyclohydrolase; Bifunctional purine biosynthesis protein PurH; KEGG: son:SO0442 phosphoribosylaminoimidazolecarboxamide formyltransferase | 0.968 |
guaA | purK | Sama_2358 | Sama_1063 | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | 5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) | 0.871 |
guaA | purL | Sama_2358 | Sama_2350 | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate | 0.981 |
guaA | purM | Sama_2358 | Sama_2097 | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | KEGG: son:SO2760 phosphoribosylformylglycinamidine cyclo-ligase | 0.929 |
guaA | purN | Sama_2358 | Sama_2098 | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate | 0.869 |
guaB | guaA | Sama_2359 | Sama_2358 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | 0.999 |
guaB | purC | Sama_2359 | Sama_0491 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family | 0.786 |
guaB | purD | Sama_2359 | Sama_0394 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | Phosphoribosylamine---glycine ligase; Belongs to the GARS family | 0.919 |
guaB | purE | Sama_2359 | Sama_1064 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | 5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) | 0.871 |
guaB | purF | Sama_2359 | Sama_2146 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine | 0.929 |
guaB | purH | Sama_2359 | Sama_0395 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | Phosphoribosylaminoimidazolecarboxamide formyltransferase / imp cyclohydrolase; Bifunctional purine biosynthesis protein PurH; KEGG: son:SO0442 phosphoribosylaminoimidazolecarboxamide formyltransferase | 0.990 |
guaB | purK | Sama_2359 | Sama_1063 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | 5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) | 0.805 |
guaB | purL | Sama_2359 | Sama_2350 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate | 0.887 |
guaB | purM | Sama_2359 | Sama_2097 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | KEGG: son:SO2760 phosphoribosylformylglycinamidine cyclo-ligase | 0.860 |
guaB | purN | Sama_2359 | Sama_2098 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate | 0.836 |