node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Sama_0875 | Sama_1496 | Sama_0875 | Sama_1496 | Anti sigma-E protein, RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish [...] | KEGG: son:SO2914 hypothetical protein. | 0.696 |
Sama_0875 | Sama_2593 | Sama_0875 | Sama_2593 | Anti sigma-E protein, RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish [...] | KEGG: son:SO1163 hypothetical protein; Belongs to the UPF0250 family. | 0.574 |
Sama_0875 | Sama_3172 | Sama_0875 | Sama_3172 | Anti sigma-E protein, RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish [...] | Met repressor; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. | 0.664 |
Sama_0875 | lptE | Sama_0875 | Sama_2583 | Anti sigma-E protein, RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish [...] | Rare lipoprotein B; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane. | 0.437 |
Sama_0875 | rraB | Sama_0875 | Sama_3138 | Anti sigma-E protein, RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish [...] | Conserved hypothetical protein; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. | 0.726 |
Sama_0875 | yihI | Sama_0875 | Sama_0089 | Anti sigma-E protein, RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish [...] | Conserved hypothetical protein; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family. | 0.626 |
Sama_1496 | Sama_0875 | Sama_1496 | Sama_0875 | KEGG: son:SO2914 hypothetical protein. | Anti sigma-E protein, RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish [...] | 0.696 |
Sama_1496 | Sama_2593 | Sama_1496 | Sama_2593 | KEGG: son:SO2914 hypothetical protein. | KEGG: son:SO1163 hypothetical protein; Belongs to the UPF0250 family. | 0.520 |
Sama_1496 | Sama_3172 | Sama_1496 | Sama_3172 | KEGG: son:SO2914 hypothetical protein. | Met repressor; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. | 0.758 |
Sama_1496 | lptE | Sama_1496 | Sama_2583 | KEGG: son:SO2914 hypothetical protein. | Rare lipoprotein B; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane. | 0.713 |
Sama_1496 | rraB | Sama_1496 | Sama_3138 | KEGG: son:SO2914 hypothetical protein. | Conserved hypothetical protein; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. | 0.773 |
Sama_1496 | yihI | Sama_1496 | Sama_0089 | KEGG: son:SO2914 hypothetical protein. | Conserved hypothetical protein; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family. | 0.779 |
Sama_2592 | Sama_2593 | Sama_2592 | Sama_2593 | Penicillin-binding protein 6. Serine peptidase. MEROPS family S11; KEGG: son:SO1164 D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. | KEGG: son:SO1163 hypothetical protein; Belongs to the UPF0250 family. | 0.593 |
Sama_2592 | lipA | Sama_2592 | Sama_2595 | Penicillin-binding protein 6. Serine peptidase. MEROPS family S11; KEGG: son:SO1164 D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.442 |
Sama_2592 | lipB | Sama_2592 | Sama_2594 | Penicillin-binding protein 6. Serine peptidase. MEROPS family S11; KEGG: son:SO1164 D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.442 |
Sama_2592 | lptE | Sama_2592 | Sama_2583 | Penicillin-binding protein 6. Serine peptidase. MEROPS family S11; KEGG: son:SO1164 D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. | Rare lipoprotein B; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane. | 0.432 |
Sama_2592 | rlpA | Sama_2592 | Sama_2591 | Penicillin-binding protein 6. Serine peptidase. MEROPS family S11; KEGG: son:SO1164 D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. | Rare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. | 0.604 |
Sama_2593 | Sama_0875 | Sama_2593 | Sama_0875 | KEGG: son:SO1163 hypothetical protein; Belongs to the UPF0250 family. | Anti sigma-E protein, RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish [...] | 0.574 |
Sama_2593 | Sama_1496 | Sama_2593 | Sama_1496 | KEGG: son:SO1163 hypothetical protein; Belongs to the UPF0250 family. | KEGG: son:SO2914 hypothetical protein. | 0.520 |
Sama_2593 | Sama_2592 | Sama_2593 | Sama_2592 | KEGG: son:SO1163 hypothetical protein; Belongs to the UPF0250 family. | Penicillin-binding protein 6. Serine peptidase. MEROPS family S11; KEGG: son:SO1164 D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. | 0.593 |