STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FRAAL1502Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (202 aa)    
Predicted Functional Partners:
rph
Ribonuclease PH; Function of strongly homologous gene; enzyme; Belongs to the RNase PH family.
 
    0.992
guaA
GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP.
 
 
 0.979
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
  
 0.940
guaB
IMP dehydrogeanse; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 0.929
FRAAL1140
Putative inosine-5'-monophosphate dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.
  
 0.928
FRAAL6235
Putative transcriptional regulator (partial match); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; regulator.
 
  
 0.923
surE
Acid phosphatase SurE, survival protein; Function of strongly homologous gene; enzyme.
    
 0.906
murI
Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.
 
    0.875
FRAAL4334
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
 
    0.780
FRAAL1260
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
     
 0.739
Your Current Organism:
Frankia alni
NCBI taxonomy Id: 326424
Other names: F. alni ACN14a, Frankia alni ACN14a, Frankia alni str. ACN14a, Frankia alni strain ACN14a, Frankia sp. ACN14a
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.