node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FRAAL0721 | FRAAL5018 | FRAAL0721 | FRAAL5018 | Hypothetical protein; No homology to any previously reported sequences. | Putative ATP/GTP binding protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | 0.737 |
FRAAL0721 | clpB-2 | FRAAL0721 | FRAAL6643 | Hypothetical protein; No homology to any previously reported sequences. | ATP-dependent protease, Hsp 100, part of multi-chaperone system with DnaK, DnaJ, and GrpE; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.498 |
FRAAL0721 | dnaK-2 | FRAAL0721 | FRAAL6639 | Hypothetical protein; No homology to any previously reported sequences. | Chaperone Hsp70 in DNA biosynthesis/cell division; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.874 |
FRAAL0721 | grpE | FRAAL0721 | FRAAL2604 | Hypothetical protein; No homology to any previously reported sequences. | Hsp 24 nucleotide exchange factor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several roun [...] | 0.606 |
FRAAL0721 | grpE-2 | FRAAL0721 | FRAAL6640 | Hypothetical protein; No homology to any previously reported sequences. | Heat shock protein (HSP-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several r [...] | 0.606 |
FRAAL0721 | htpG | FRAAL0721 | FRAAL3986 | Hypothetical protein; No homology to any previously reported sequences. | Molecular chaperone Hsp90, heat shock protein; Molecular chaperone. Has ATPase activity. | 0.737 |
FRAAL5018 | FRAAL0721 | FRAAL5018 | FRAAL0721 | Putative ATP/GTP binding protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Hypothetical protein; No homology to any previously reported sequences. | 0.737 |
FRAAL5018 | clpB-2 | FRAAL5018 | FRAAL6643 | Putative ATP/GTP binding protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | ATP-dependent protease, Hsp 100, part of multi-chaperone system with DnaK, DnaJ, and GrpE; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.557 |
FRAAL5018 | dnaJ | FRAAL5018 | FRAAL2007 | Putative ATP/GTP binding protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Heat shock protein (Hsp40), co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent [...] | 0.760 |
FRAAL5018 | dnaJ-2 | FRAAL5018 | FRAAL2603 | Putative ATP/GTP binding protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Curved DNA-binding protein, co-chaperone of DnaK (Hsp40 family); Function of strongly homologous gene; molecular chaperone. | 0.790 |
FRAAL5018 | dnaJ-3 | FRAAL5018 | FRAAL6641 | Putative ATP/GTP binding protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Heat shock protein (Hsp40), co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent [...] | 0.760 |
FRAAL5018 | dnaK-2 | FRAAL5018 | FRAAL6639 | Putative ATP/GTP binding protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Chaperone Hsp70 in DNA biosynthesis/cell division; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.789 |
FRAAL5018 | grpE | FRAAL5018 | FRAAL2604 | Putative ATP/GTP binding protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Hsp 24 nucleotide exchange factor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several roun [...] | 0.576 |
FRAAL5018 | grpE-2 | FRAAL5018 | FRAAL6640 | Putative ATP/GTP binding protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Heat shock protein (HSP-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several r [...] | 0.576 |
clpB-2 | FRAAL0721 | FRAAL6643 | FRAAL0721 | ATP-dependent protease, Hsp 100, part of multi-chaperone system with DnaK, DnaJ, and GrpE; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Hypothetical protein; No homology to any previously reported sequences. | 0.498 |
clpB-2 | FRAAL5018 | FRAAL6643 | FRAAL5018 | ATP-dependent protease, Hsp 100, part of multi-chaperone system with DnaK, DnaJ, and GrpE; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Putative ATP/GTP binding protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | 0.557 |
clpB-2 | dnaJ | FRAAL6643 | FRAAL2007 | ATP-dependent protease, Hsp 100, part of multi-chaperone system with DnaK, DnaJ, and GrpE; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Heat shock protein (Hsp40), co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent [...] | 0.631 |
clpB-2 | dnaJ-2 | FRAAL6643 | FRAAL2603 | ATP-dependent protease, Hsp 100, part of multi-chaperone system with DnaK, DnaJ, and GrpE; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Curved DNA-binding protein, co-chaperone of DnaK (Hsp40 family); Function of strongly homologous gene; molecular chaperone. | 0.631 |
clpB-2 | dnaJ-3 | FRAAL6643 | FRAAL6641 | ATP-dependent protease, Hsp 100, part of multi-chaperone system with DnaK, DnaJ, and GrpE; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Heat shock protein (Hsp40), co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent [...] | 0.760 |
clpB-2 | dnaK-2 | FRAAL6643 | FRAAL6639 | ATP-dependent protease, Hsp 100, part of multi-chaperone system with DnaK, DnaJ, and GrpE; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone Hsp70 in DNA biosynthesis/cell division; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.786 |