STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (427 aa)    
Predicted Functional Partners:
purB
Adenylosuccinate lyase (Adenylosuccinase) (ASL); Function of strongly homologous gene; enzyme; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
 
 0.999
guaB
IMP dehydrogeanse; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
 
 0.992
purH
Bifunctional: IMP cyclohydrolase (N-terminal); Function of strongly homologous gene; enzyme.
  
 0.989
FRAAL1140
Putative inosine-5'-monophosphate dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.
 
 
 0.976
guaA
GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP.
 
  
 0.954
argG
Argininosuccinate synthase (Citrulline--aspartate ligase); Function of strongly homologous gene; enzyme; Belongs to the argininosuccinate synthase family. Type 1 subfamily.
  
 
 0.937
pyrB
Aspartate carbamoyltransferase (Aspartate transcarbamylase) (ATCase); Function of strongly homologous gene; enzyme; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
  
 
 0.931
aspC
Aspartate aminotransferase (Transaminase A) (ASPAT); Function of strongly homologous gene; enzyme.
  
 0.921
surE
Acid phosphatase SurE, survival protein; Function of strongly homologous gene; enzyme.
    
 0.916
purD
Phosphoribosylglycinamide synthetase (GAR synthetase); Function of strongly homologous gene; enzyme; Belongs to the GARS family.
  
 
 0.915
Your Current Organism:
Frankia alni
NCBI taxonomy Id: 326424
Other names: F. alni ACN14a, Frankia alni ACN14a, Frankia alni str. ACN14a, Frankia alni strain ACN14a, Frankia sp. ACN14a
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