STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cagg_20344-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. (343 aa)    
Predicted Functional Partners:
Cagg_2033
Acetaldehyde dehydrogenase (acetylating); Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.
 
 0.999
Cagg_2039
4-oxalocrotonate decarboxylase; PFAM: fumarylacetoacetate (FAA) hydrolase; KEGG: cau:Caur_1357 4-oxalocrotonate decarboxylase.
 
 
 0.990
Cagg_2037
PFAM: fumarylacetoacetate (FAA) hydrolase; KEGG: cau:Caur_1355 hydratase/decarboxylase.
 
  
 0.906
Cagg_2036
TIGRFAM: 4-oxalocrotonate tautomerase family enzyme; PFAM: 4-oxalocrotonate tautomerase; KEGG: cau:Caur_1354 4-oxalocrotonate tautomerase.
 
   
 0.889
Cagg_2031
KEGG: cau:Caur_1348 catechol 2,3 dioxygenase; TIGRFAM: catechol 2,3 dioxygenase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase.
 
   
 0.870
Cagg_2032
PFAM: regulatory protein IclR; Transcriptional regulator IclR; KEGG: cau:Caur_1349 transcriptional regulator IclR.
 
     0.866
Cagg_2035
PFAM: flavin reductase domain protein FMN-binding; KEGG: cau:Caur_1352 flavin reductase domain-containing protein.
 
   
 0.848
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
  
 0.768
Cagg_2030
PFAM: 4-hydroxyphenylacetate 3-hydroxylase; KEGG: cau:Caur_1347 4-hydroxyphenylacetate 3-hydroxylase.
 
     0.738
ilvD
KEGG: cau:Caur_2851 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family.
  
  
 0.732
Your Current Organism:
Chloroflexus aggregans
NCBI taxonomy Id: 326427
Other names: C. aggregans DSM 9485, Chloroflexus aggregans DSM 9485, Chloroflexus aggregans MD-66, Chloroflexus aggregans str. DSM 9485, Chloroflexus aggregans strain DSM 9485
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