node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
guaA | hisA | PSHAa0649 | PSHAb0489 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.833 |
guaA | hisB | PSHAa0649 | PSHAb0491 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | Modular bifunctional: histidinol-phosphatase (N-terminal); Function of homologous gene experimentally demonstrated in an other organism; enzyme; In the N-terminal section; belongs to the histidinol- phosphatase family. | 0.663 |
guaA | hisF | PSHAa0649 | PSHAb0483 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | Imidazole glycerol phosphate synthase, subunit with HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.450 |
guaA | hisH | PSHAa0649 | PSHAb0490 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | Imidazole glycerol-phosphate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.521 |
guaA | hisI | PSHAa0649 | PSHAb0482 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | Bifunctional: phosphoribosyl-AMP cyclohydrolase (N-terminal); Function of homologous gene experimentally demonstrated in an other organism; enzyme; In the N-terminal section; belongs to the PRA-CH family. | 0.586 |
guaA | trpCF | PSHAa0649 | PSHAa1290 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | Bifunctional: indole-3-glycerolphosphate synthetase (N-terminal); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the TrpC family. | 0.670 |
hisA | guaA | PSHAb0489 | PSHAa0649 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 0.833 |
hisA | hisB | PSHAb0489 | PSHAb0491 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Modular bifunctional: histidinol-phosphatase (N-terminal); Function of homologous gene experimentally demonstrated in an other organism; enzyme; In the N-terminal section; belongs to the histidinol- phosphatase family. | 0.999 |
hisA | hisC | PSHAb0489 | PSHAb0492 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Histidinol phosphate aminotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.997 |
hisA | hisD | PSHAb0489 | PSHAb0493 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Bifunctional HisD: L-histidinal:NAD+ dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.997 |
hisA | hisF | PSHAb0489 | PSHAb0483 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Imidazole glycerol phosphate synthase, subunit with HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | PSHAb0489 | PSHAb0494 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.997 |
hisA | hisH | PSHAb0489 | PSHAb0490 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Imidazole glycerol-phosphate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.999 |
hisA | hisI | PSHAb0489 | PSHAb0482 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Bifunctional: phosphoribosyl-AMP cyclohydrolase (N-terminal); Function of homologous gene experimentally demonstrated in an other organism; enzyme; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
hisA | serB | PSHAb0489 | PSHAa0661 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Putative phosphoserine phosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | 0.728 |
hisA | trpCF | PSHAb0489 | PSHAa1290 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Bifunctional: indole-3-glycerolphosphate synthetase (N-terminal); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the TrpC family. | 0.649 |
hisB | guaA | PSHAb0491 | PSHAa0649 | Modular bifunctional: histidinol-phosphatase (N-terminal); Function of homologous gene experimentally demonstrated in an other organism; enzyme; In the N-terminal section; belongs to the histidinol- phosphatase family. | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 0.663 |
hisB | hisA | PSHAb0491 | PSHAb0489 | Modular bifunctional: histidinol-phosphatase (N-terminal); Function of homologous gene experimentally demonstrated in an other organism; enzyme; In the N-terminal section; belongs to the histidinol- phosphatase family. | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.999 |
hisB | hisC | PSHAb0491 | PSHAb0492 | Modular bifunctional: histidinol-phosphatase (N-terminal); Function of homologous gene experimentally demonstrated in an other organism; enzyme; In the N-terminal section; belongs to the histidinol- phosphatase family. | Histidinol phosphate aminotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.999 |
hisB | hisD | PSHAb0491 | PSHAb0493 | Modular bifunctional: histidinol-phosphatase (N-terminal); Function of homologous gene experimentally demonstrated in an other organism; enzyme; In the N-terminal section; belongs to the histidinol- phosphatase family. | Bifunctional HisD: L-histidinal:NAD+ dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |