node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AM1_1143 | hrcA | AM1_1143 | AM1_1142 | Rhodanese family protein. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.718 |
AM1_2057 | AM1_5597 | AM1_2057 | AM1_5597 | DnaK family protein; Belongs to the heat shock protein 70 family. | Conserved hypothetical protein. | 0.950 |
AM1_2057 | clpP | AM1_2057 | AM1_2330 | DnaK family protein; Belongs to the heat shock protein 70 family. | ATP-dependent Clp protease, proteolytic subunit ClpP, putative; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.405 |
AM1_2057 | clpP-2 | AM1_2057 | AM1_2331 | DnaK family protein; Belongs to the heat shock protein 70 family. | ATP-dependent Clp protease, proteolytic subunit ClpP, putative; Belongs to the peptidase S14 family. | 0.405 |
AM1_2057 | grpE | AM1_2057 | AM1_0421 | DnaK family protein; Belongs to the heat shock protein 70 family. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.935 |
AM1_2057 | hrcA | AM1_2057 | AM1_1142 | DnaK family protein; Belongs to the heat shock protein 70 family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.736 |
AM1_5597 | AM1_2057 | AM1_5597 | AM1_2057 | Conserved hypothetical protein. | DnaK family protein; Belongs to the heat shock protein 70 family. | 0.950 |
AM1_5597 | clpP | AM1_5597 | AM1_2330 | Conserved hypothetical protein. | ATP-dependent Clp protease, proteolytic subunit ClpP, putative; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.454 |
AM1_5597 | clpP-2 | AM1_5597 | AM1_2331 | Conserved hypothetical protein. | ATP-dependent Clp protease, proteolytic subunit ClpP, putative; Belongs to the peptidase S14 family. | 0.454 |
AM1_5597 | dnaK | AM1_5597 | AM1_0422 | Conserved hypothetical protein. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.835 |
AM1_5597 | dnaK-2 | AM1_5597 | AM1_2440 | Conserved hypothetical protein. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.835 |
AM1_5597 | dnaK-3 | AM1_5597 | AM1_5692 | Conserved hypothetical protein. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.835 |
AM1_5597 | hrcA | AM1_5597 | AM1_1142 | Conserved hypothetical protein. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.826 |
clpP | AM1_2057 | AM1_2330 | AM1_2057 | ATP-dependent Clp protease, proteolytic subunit ClpP, putative; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | DnaK family protein; Belongs to the heat shock protein 70 family. | 0.405 |
clpP | AM1_5597 | AM1_2330 | AM1_5597 | ATP-dependent Clp protease, proteolytic subunit ClpP, putative; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Conserved hypothetical protein. | 0.454 |
clpP | clpP-2 | AM1_2330 | AM1_2331 | ATP-dependent Clp protease, proteolytic subunit ClpP, putative; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | ATP-dependent Clp protease, proteolytic subunit ClpP, putative; Belongs to the peptidase S14 family. | 0.717 |
clpP | dnaK | AM1_2330 | AM1_0422 | ATP-dependent Clp protease, proteolytic subunit ClpP, putative; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.461 |
clpP | dnaK-2 | AM1_2330 | AM1_2440 | ATP-dependent Clp protease, proteolytic subunit ClpP, putative; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.463 |
clpP | dnaK-3 | AM1_2330 | AM1_5692 | ATP-dependent Clp protease, proteolytic subunit ClpP, putative; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.461 |
clpP | grpE | AM1_2330 | AM1_0421 | ATP-dependent Clp protease, proteolytic subunit ClpP, putative; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.497 |