STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
rad50DNA double-strand break repair Rad50 ATPase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily (886 aa)    
Predicted Functional Partners:
mre11
DNA double-strand break repair protein Mre11; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity (By similarity). Recruited immediately to chromosomal DNA after gamma irradiation, and remains DNA bound in the course of DNA repair; Belongs to the MRE11/RAD32 family
 
 
 0.999
Saci_2046
annotation not available
   
 
 0.999
P4
DNA double-strand break repair helicase HerA; Involved in DNA double-strand break (DSB) repair. Acts probably with NurA to stimulate resection of the 5' strand and produce the long 3' single-strand that is required for RadA loading (By similarity). Exhibits DNA-dependent ATPase activity and DNA helicase activity. Loads on either a 3' or a 5' DNA tail for subsequent DNA unwinding; Belongs to the HerA family
 
   
 0.979
nurA
DNA double-strand break repair nuclease NurA; Involved in DNA double-strand break (DSB) repair. Acts probably with HerA to stimulate resection of the 5' strand and produce the long 3' single-strand that is required for RadA loading (By similarity). Exhibits both single- stranded endonuclease activity and 5'-3' exonuclease activity on single-stranded and double-stranded DNA
 
   
 0.970
radA
DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules
 
 
 0.676
Saci_0054
Conserved protein; Contains 60 aa repeated motif
     
 0.653
fen
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...]
  
 
 0.649
Saci_0896
annotation not available
  
 
 0.634
lig
DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair
  
 
 0.589
Saci_0975
Single strand DNA binding protein; SSB; Function is confirmed in Sulfolobus solfataricus
   
 
 0.585
Your Current Organism:
Sulfolobus acidocaldarius
NCBI taxonomy Id: 330779
Other names: S. acidocaldarius DSM 639, Sulfolobus acidocaldarius, Sulfolobus acidocaldarius ATCC 33909, Sulfolobus acidocaldarius DSM 639, Sulfolobus acidocaldarius DSM639, Sulfolobus acidocaldarius NCIB 11770
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