node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Saci_0192 | Saci_1326 | Saci_0192 | Saci_1326 | XPD/Rad3 related DNA helicase; ATP-dependent 5'-3' DNA helicase involved in nucleotide excision repair (NER) of DNA; Belongs to the helicase family. RAD3/XPD subfamily. | XPB/RAD25-related helicase. | 0.958 |
Saci_0192 | fen | Saci_0192 | Saci_0775 | XPD/Rad3 related DNA helicase; ATP-dependent 5'-3' DNA helicase involved in nucleotide excision repair (NER) of DNA; Belongs to the helicase family. RAD3/XPD subfamily. | XPG/RAD25 related endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...] | 0.963 |
Saci_0192 | rpoB | Saci_0192 | Saci_0693 | XPD/Rad3 related DNA helicase; ATP-dependent 5'-3' DNA helicase involved in nucleotide excision repair (NER) of DNA; Belongs to the helicase family. RAD3/XPD subfamily. | DNA directed RNA polymerase subunit B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.975 |
Saci_0192 | rpoD | Saci_0192 | Saci_0083 | XPD/Rad3 related DNA helicase; ATP-dependent 5'-3' DNA helicase involved in nucleotide excision repair (NER) of DNA; Belongs to the helicase family. RAD3/XPD subfamily. | DNA-directed RNA polymerase subunit D; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family. | 0.973 |
Saci_0192 | rpoH | Saci_0192 | Saci_0694 | XPD/Rad3 related DNA helicase; ATP-dependent 5'-3' DNA helicase involved in nucleotide excision repair (NER) of DNA; Belongs to the helicase family. RAD3/XPD subfamily. | DNA-directed RNA polymerase, subunit H; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. | 0.976 |
Saci_0192 | rpoK | Saci_0192 | Saci_1370 | XPD/Rad3 related DNA helicase; ATP-dependent 5'-3' DNA helicase involved in nucleotide excision repair (NER) of DNA; Belongs to the helicase family. RAD3/XPD subfamily. | DNA-directed RNA polymerase subunit K; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.978 |
Saci_0192 | rpoN | Saci_0192 | Saci_0087 | XPD/Rad3 related DNA helicase; ATP-dependent 5'-3' DNA helicase involved in nucleotide excision repair (NER) of DNA; Belongs to the helicase family. RAD3/XPD subfamily. | DNA-directed RNA polymerase subunit N; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.975 |
Saci_0192 | rpoP | Saci_0192 | Saci_0864 | XPD/Rad3 related DNA helicase; ATP-dependent 5'-3' DNA helicase involved in nucleotide excision repair (NER) of DNA; Belongs to the helicase family. RAD3/XPD subfamily. | DNA directed RNA polymerase subunit P-like protein; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family. | 0.976 |
Saci_0192 | tbp | Saci_0192 | Saci_1336 | XPD/Rad3 related DNA helicase; ATP-dependent 5'-3' DNA helicase involved in nucleotide excision repair (NER) of DNA; Belongs to the helicase family. RAD3/XPD subfamily. | TATA-binding protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity). | 0.976 |
Saci_0192 | tfe | Saci_0192 | Saci_0652 | XPD/Rad3 related DNA helicase; ATP-dependent 5'-3' DNA helicase involved in nucleotide excision repair (NER) of DNA; Belongs to the helicase family. RAD3/XPD subfamily. | Conserved Archaeal protein; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Se [...] | 0.982 |
Saci_1326 | Saci_0192 | Saci_1326 | Saci_0192 | XPB/RAD25-related helicase. | XPD/Rad3 related DNA helicase; ATP-dependent 5'-3' DNA helicase involved in nucleotide excision repair (NER) of DNA; Belongs to the helicase family. RAD3/XPD subfamily. | 0.958 |
Saci_1326 | fen | Saci_1326 | Saci_0775 | XPB/RAD25-related helicase. | XPG/RAD25 related endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...] | 0.921 |
Saci_1326 | rpoB | Saci_1326 | Saci_0693 | XPB/RAD25-related helicase. | DNA directed RNA polymerase subunit B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.946 |
Saci_1326 | rpoD | Saci_1326 | Saci_0083 | XPB/RAD25-related helicase. | DNA-directed RNA polymerase subunit D; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family. | 0.940 |
Saci_1326 | rpoH | Saci_1326 | Saci_0694 | XPB/RAD25-related helicase. | DNA-directed RNA polymerase, subunit H; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. | 0.954 |
Saci_1326 | rpoK | Saci_1326 | Saci_1370 | XPB/RAD25-related helicase. | DNA-directed RNA polymerase subunit K; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.938 |
Saci_1326 | rpoN | Saci_1326 | Saci_0087 | XPB/RAD25-related helicase. | DNA-directed RNA polymerase subunit N; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.936 |
Saci_1326 | rpoP | Saci_1326 | Saci_0864 | XPB/RAD25-related helicase. | DNA directed RNA polymerase subunit P-like protein; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family. | 0.936 |
Saci_1326 | tbp | Saci_1326 | Saci_1336 | XPB/RAD25-related helicase. | TATA-binding protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity). | 0.945 |
Saci_1326 | tfe | Saci_1326 | Saci_0652 | XPB/RAD25-related helicase. | Conserved Archaeal protein; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Se [...] | 0.959 |