node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Saci_0074 | Saci_0975 | Saci_0074 | Saci_0975 | DNA polymerase B3. | Single strand DNA binding protein; SSB; Function is confirmed in Sulfolobus solfataricus. | 0.694 |
Saci_0074 | dpo1 | Saci_0074 | Saci_1537 | DNA polymerase B3. | DNA polymerase I; This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. | 0.950 |
Saci_0074 | fen | Saci_0074 | Saci_0775 | DNA polymerase B3. | XPG/RAD25 related endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...] | 0.964 |
Saci_0074 | lig | Saci_0074 | Saci_0788 | DNA polymerase B3. | Thermostable DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. | 0.800 |
Saci_0074 | pcn2 | Saci_0074 | Saci_1280 | DNA polymerase B3. | DNA polymerase sliding clamp C; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.909 |
Saci_0074 | pcnA | Saci_0074 | Saci_0826 | DNA polymerase B3. | DNA polymerase sliding clamp A; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.914 |
Saci_0074 | polIV | Saci_0074 | Saci_0554 | DNA polymerase B3. | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. | 0.987 |
Saci_0074 | priL | Saci_0074 | Saci_1542 | DNA polymerase B3. | DNA primase large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.984 |
Saci_0074 | rfcL | Saci_0074 | Saci_0906 | DNA polymerase B3. | Replication factor C; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 0.762 |
Saci_0074 | rfcS | Saci_0074 | Saci_0907 | DNA polymerase B3. | Replication factor C; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. | 0.724 |
Saci_0975 | Saci_0074 | Saci_0975 | Saci_0074 | Single strand DNA binding protein; SSB; Function is confirmed in Sulfolobus solfataricus. | DNA polymerase B3. | 0.694 |
Saci_0975 | dpo1 | Saci_0975 | Saci_1537 | Single strand DNA binding protein; SSB; Function is confirmed in Sulfolobus solfataricus. | DNA polymerase I; This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. | 0.746 |
Saci_0975 | fen | Saci_0975 | Saci_0775 | Single strand DNA binding protein; SSB; Function is confirmed in Sulfolobus solfataricus. | XPG/RAD25 related endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...] | 0.760 |
Saci_0975 | lig | Saci_0975 | Saci_0788 | Single strand DNA binding protein; SSB; Function is confirmed in Sulfolobus solfataricus. | Thermostable DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. | 0.753 |
Saci_0975 | pcn2 | Saci_0975 | Saci_1280 | Single strand DNA binding protein; SSB; Function is confirmed in Sulfolobus solfataricus. | DNA polymerase sliding clamp C; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.903 |
Saci_0975 | pcnA | Saci_0975 | Saci_0826 | Single strand DNA binding protein; SSB; Function is confirmed in Sulfolobus solfataricus. | DNA polymerase sliding clamp A; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.898 |
Saci_0975 | polIV | Saci_0975 | Saci_0554 | Single strand DNA binding protein; SSB; Function is confirmed in Sulfolobus solfataricus. | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. | 0.639 |
Saci_0975 | priL | Saci_0975 | Saci_1542 | Single strand DNA binding protein; SSB; Function is confirmed in Sulfolobus solfataricus. | DNA primase large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.897 |
Saci_0975 | rfcL | Saci_0975 | Saci_0906 | Single strand DNA binding protein; SSB; Function is confirmed in Sulfolobus solfataricus. | Replication factor C; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 0.857 |
Saci_0975 | rfcS | Saci_0975 | Saci_0907 | Single strand DNA binding protein; SSB; Function is confirmed in Sulfolobus solfataricus. | Replication factor C; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. | 0.834 |