node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Saci_0192 | Saci_1497 | Saci_0192 | Saci_1497 | XPD/Rad3 related DNA helicase; ATP-dependent 5'-3' DNA helicase involved in nucleotide excision repair (NER) of DNA; Belongs to the helicase family. RAD3/XPD subfamily. | Endonuclease III. | 0.646 |
Saci_0192 | fen | Saci_0192 | Saci_0775 | XPD/Rad3 related DNA helicase; ATP-dependent 5'-3' DNA helicase involved in nucleotide excision repair (NER) of DNA; Belongs to the helicase family. RAD3/XPD subfamily. | XPG/RAD25 related endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...] | 0.963 |
Saci_0192 | ogt | Saci_0192 | Saci_1260 | XPD/Rad3 related DNA helicase; ATP-dependent 5'-3' DNA helicase involved in nucleotide excision repair (NER) of DNA; Belongs to the helicase family. RAD3/XPD subfamily. | Methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. | 0.578 |
Saci_0192 | polIV | Saci_0192 | Saci_0554 | XPD/Rad3 related DNA helicase; ATP-dependent 5'-3' DNA helicase involved in nucleotide excision repair (NER) of DNA; Belongs to the helicase family. RAD3/XPD subfamily. | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. | 0.795 |
Saci_0887 | ogt | Saci_0887 | Saci_1260 | Conserved Prokaryal protein. | Methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. | 0.609 |
Saci_1262 | Saci_1264 | Saci_1262 | Saci_1264 | Conserved protein. | Endonuclease III related protein. | 0.958 |
Saci_1262 | ogt | Saci_1262 | Saci_1260 | Conserved protein. | Methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. | 0.826 |
Saci_1262 | rps27e | Saci_1262 | Saci_1276 | Conserved protein. | SSU ribosomal protein S27E. | 0.731 |
Saci_1262 | sucC | Saci_1262 | Saci_1265 | Conserved protein. | succinyl-CoA synthetase beta chain. | 0.837 |
Saci_1262 | thrS-cat | Saci_1262 | Saci_1261 | Conserved protein. | threonine-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also activates L-serine and transfers it to tRNA(Thr) but cannot deacylate incorrectly charged amino acid; unlike most archaea the editing function is found in a freestanding protein. | 0.632 |
Saci_1264 | Saci_1262 | Saci_1264 | Saci_1262 | Endonuclease III related protein. | Conserved protein. | 0.958 |
Saci_1264 | ogt | Saci_1264 | Saci_1260 | Endonuclease III related protein. | Methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. | 0.759 |
Saci_1264 | sucC | Saci_1264 | Saci_1265 | Endonuclease III related protein. | succinyl-CoA synthetase beta chain. | 0.845 |
Saci_1264 | thrS-cat | Saci_1264 | Saci_1261 | Endonuclease III related protein. | threonine-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also activates L-serine and transfers it to tRNA(Thr) but cannot deacylate incorrectly charged amino acid; unlike most archaea the editing function is found in a freestanding protein. | 0.597 |
Saci_1497 | Saci_0192 | Saci_1497 | Saci_0192 | Endonuclease III. | XPD/Rad3 related DNA helicase; ATP-dependent 5'-3' DNA helicase involved in nucleotide excision repair (NER) of DNA; Belongs to the helicase family. RAD3/XPD subfamily. | 0.646 |
Saci_1497 | fen | Saci_1497 | Saci_0775 | Endonuclease III. | XPG/RAD25 related endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...] | 0.735 |
Saci_1497 | ogt | Saci_1497 | Saci_1260 | Endonuclease III. | Methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. | 0.648 |
Saci_1497 | polIV | Saci_1497 | Saci_0554 | Endonuclease III. | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. | 0.638 |
fen | Saci_0192 | Saci_0775 | Saci_0192 | XPG/RAD25 related endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...] | XPD/Rad3 related DNA helicase; ATP-dependent 5'-3' DNA helicase involved in nucleotide excision repair (NER) of DNA; Belongs to the helicase family. RAD3/XPD subfamily. | 0.963 |
fen | Saci_1497 | Saci_0775 | Saci_1497 | XPG/RAD25 related endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...] | Endonuclease III. | 0.735 |