STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Saci_1304Homocitrate synthase; Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate. Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway. Does not display 2-isopropylmalate synthase and citramalate synthase activities since it cannot use 2-oxoisovalerate or pyruvate as substrate. (468 aa)    
Predicted Functional Partners:
leuD
3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
 
 
 0.992
leu2
3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 
 0.992
ilvD
Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family.
 
 
 0.976
mas
Malate synthase.
 
 
 0.929
Saci_0025
Acetyl-coenzyme A synthetase.
  
 
 0.923
Saci_0306
Acetyl-coenzyme A synthetase.
  
 
 0.923
Saci_1774
Acetyl-coenzyme A synthetase.
  
 
 0.923
acs-2
Acetyl-coenzyme A synthetase.
  
 
 0.923
Saci_2235
acyl-CoA synthetase.
  
 
 0.923
acsA
Acetyl-coenzyme A synthetase.
  
 
 0.923
Your Current Organism:
Sulfolobus acidocaldarius DSM 639
NCBI taxonomy Id: 330779
Other names: S. acidocaldarius DSM 639, Sulfolobus acidocaldarius ATCC 33909, Sulfolobus acidocaldarius NCIB 11770
Server load: medium (50%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.