node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Neut_0517 | Neut_1445 | Neut_0517 | Neut_1445 | PFAM: TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein; KEGG: neu:NE1600 TPR repeat. | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: neu:NE1155 DnaJ N-terminal domain:DnaJ C terminal domain. | 0.847 |
Neut_0517 | dnaJ | Neut_0517 | Neut_0413 | PFAM: TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein; KEGG: neu:NE1600 TPR repeat. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.847 |
Neut_0517 | dnaK | Neut_0517 | Neut_0412 | PFAM: TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein; KEGG: neu:NE1600 TPR repeat. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.971 |
Neut_0517 | htpG | Neut_0517 | Neut_0937 | PFAM: TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein; KEGG: neu:NE1600 TPR repeat. | Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity. | 0.974 |
Neut_1445 | Neut_0517 | Neut_1445 | Neut_0517 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: neu:NE1155 DnaJ N-terminal domain:DnaJ C terminal domain. | PFAM: TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein; KEGG: neu:NE1600 TPR repeat. | 0.847 |
Neut_1445 | Neut_2048 | Neut_1445 | Neut_2048 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: neu:NE1155 DnaJ N-terminal domain:DnaJ C terminal domain. | KEGG: neu:NE1733 ATP dependent protease, chaperonin; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | 0.724 |
Neut_1445 | clpB | Neut_1445 | Neut_0734 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: neu:NE1155 DnaJ N-terminal domain:DnaJ C terminal domain. | ATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.724 |
Neut_1445 | dnaK | Neut_1445 | Neut_0412 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: neu:NE1155 DnaJ N-terminal domain:DnaJ C terminal domain. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.997 |
Neut_1445 | groL | Neut_1445 | Neut_0206 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: neu:NE1155 DnaJ N-terminal domain:DnaJ C terminal domain. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.814 |
Neut_1445 | groS | Neut_1445 | Neut_0207 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: neu:NE1155 DnaJ N-terminal domain:DnaJ C terminal domain. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.624 |
Neut_1445 | grpE | Neut_1445 | Neut_0411 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: neu:NE1155 DnaJ N-terminal domain:DnaJ C terminal domain. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.915 |
Neut_1445 | hrcA | Neut_1445 | Neut_0769 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: neu:NE1155 DnaJ N-terminal domain:DnaJ C terminal domain. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.776 |
Neut_1445 | htpG | Neut_1445 | Neut_0937 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: neu:NE1155 DnaJ N-terminal domain:DnaJ C terminal domain. | Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity. | 0.976 |
Neut_2048 | Neut_1445 | Neut_2048 | Neut_1445 | KEGG: neu:NE1733 ATP dependent protease, chaperonin; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: neu:NE1155 DnaJ N-terminal domain:DnaJ C terminal domain. | 0.724 |
Neut_2048 | dnaJ | Neut_2048 | Neut_0413 | KEGG: neu:NE1733 ATP dependent protease, chaperonin; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.799 |
Neut_2048 | dnaK | Neut_2048 | Neut_0412 | KEGG: neu:NE1733 ATP dependent protease, chaperonin; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.979 |
Neut_2048 | groL | Neut_2048 | Neut_0206 | KEGG: neu:NE1733 ATP dependent protease, chaperonin; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.555 |
Neut_2048 | groS | Neut_2048 | Neut_0207 | KEGG: neu:NE1733 ATP dependent protease, chaperonin; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.651 |
Neut_2048 | grpE | Neut_2048 | Neut_0411 | KEGG: neu:NE1733 ATP dependent protease, chaperonin; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.829 |
Neut_2048 | hrcA | Neut_2048 | Neut_0769 | KEGG: neu:NE1733 ATP dependent protease, chaperonin; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.514 |