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hemE protein (Nitrosomonas eutropha) - STRING interaction network
"hemE" - Uroporphyrinogen decarboxylase in Nitrosomonas eutropha
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (356 aa)    
Predicted Functional Partners:
hemF
Oxygen-dependent coproporphyrinogen-III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX (301 aa)
 
 
  0.990
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps; Belongs to the HMBS family (334 aa)
 
  0.988
cysG
Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme (476 aa)
   
 
  0.968
Neut_1038
PFAM- Uroporphyrinogen III synthase HEM4; KEGG- neu-NE0591 uroporphyrinogen III synthase HEM4 (260 aa)
   
 
  0.963
Neut_0310
Oxygen-independent coproporphyrinogen-III oxidase-like protein; Involved in the biosynthesis of porphyrin-containing compound (411 aa)
   
 
  0.963
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX; Belongs to the ferrochelatase family (365 aa)
 
   
  0.943
Neut_1576
PFAM- Radical SAM domain protein; KEGG- neu-NE0329 MoaA / NifB / PqqE family (387 aa)
       
  0.932
queE
7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds (211 aa)
         
  0.925
Neut_1287
PFAM- Radical SAM domain protein; KEGG- neu-NE1518 hypothetical protein (286 aa)
   
 
    0.921
Neut_1039
PFAM- protein of unknown function DUF513, hemX; KEGG- neu-NE0592 possible uroporphyrin-III C-methyltransferase (342 aa)
   
 
  0.905
Your Current Organism:
Nitrosomonas eutropha
NCBI taxonomy Id: 335283
Other names: N. eutropha C91, Nitrosomonas eutropha, Nitrosomonas eutropha C91, Nitrosomonas eutropha str. C91, Nitrosomonas eutropha strain C91
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