Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Genes that are sometimes fused into single open reading frames.
Automated, unsupervised textmining - searching for proteins that are frequently mentioned together.
Proteins whose genes are observed to be correlated in expression, across a large number of experiments.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
KEGG- neu-NE1481 hypothetical protein (255 aa)
Predicted Functional Partners:
PFAM- protein of unknown function DUF583; KEGG- neu-NE1480 hypothetical protein (141 aa)
KEGG- neu-NE1504 hypothetical protein (461 aa)
KEGG- neu-NE0458 hypothetical protein (698 aa)
PFAM- O-antigen polymerase; KEGG- neu-NE1682 possible transmembrane protein (405 aa)
N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily (342 aa)
KEGG- neu-NE0824 hypothetical protein (182 aa)
PFAM- copper resistance D domain protein; KEGG- neu-NE2058 cytochrome c, class IC-cytochrome c, class I (714 aa)