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hisG protein (Nitrosomonas eutropha) - STRING interaction network
"hisG" - ATP phosphoribosyltransferase in Nitrosomonas eutropha
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query proteins and first shell of interactors
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second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N’-(5’-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity; Belongs to the ATP phosphoribosyltransferase family. Short subfamily (216 aa)    
Predicted Functional Partners:
hisZ
ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (390 aa)
 
  0.999
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (432 aa)
 
 
  0.997
hisE
PFAM- phosphoribosyl-ATP pyrophosphohydrolase; KEGG- neu-NE0641 phosphoribosyl-ATP pyrophosphohydrolase (117 aa)
 
 
  0.993
hisF
Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (258 aa)
 
 
  0.983
hisI
Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP (129 aa)
 
   
  0.976
hisB
PFAM- imidazoleglycerol-phosphate dehydratase; KEGG- neu-NE0646 imidazoleglycerol-phosphate dehydratase (195 aa)
 
   
  0.971
hisH
Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (212 aa)
 
   
  0.957
hisA
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM- phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM- histidine biosynthesis; KEGG- neu-NE0644 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (248 aa)
 
   
  0.936
Neut_1905
TIGRFAM- histidinol-phosphate aminotransferase; PFAM- aminotransferase, class I and II; KEGG- neu-NE0647 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily (359 aa)
 
   
  0.877
Neut_1204
Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems (212 aa)
   
        0.847
Your Current Organism:
Nitrosomonas eutropha
NCBI taxonomy Id: 335283
Other names: N. eutropha C91, Nitrosomonas eutropha, Nitrosomonas eutropha C91, Nitrosomonas eutropha str. C91, Nitrosomonas eutropha strain C91
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