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Neut_1220 protein (Nitrosomonas eutropha) - STRING interaction network
"Neut_1220" - Methylated-DNA--protein-cysteine methyltransferase in Nitrosomonas eutropha
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
Score
Neut_1220Methylated-DNA--protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction- the enzyme is irreversibly inactivated (167 aa)    
Predicted Functional Partners:
Neut_1221
DNA-O6-methylguanine--protein-cysteine S-methyltransferase; PFAM- helix-turn-helix- domain containing protein, AraC type; HhH-GPD family protein; Ada, metal-binding domain protein; AlkA domain protein; KEGG- pcu-pc1834 putative DNA-3-methyladenine glycosidase II (477 aa)
 
  0.991
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity (906 aa)
     
 
  0.560
rpoD
RNA polymerase sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth (749 aa)
     
      0.454
Neut_1222
KEGG- neu-NE0895 hypothetical protein (80 aa)
              0.447
rpoH
TIGRFAM- RNA polymerase sigma factor RpoH; PFAM- sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; KEGG- neu-NE0584 sigma-70 factor family (280 aa)
     
 
  0.444
Your Current Organism:
Nitrosomonas eutropha
NCBI taxonomy Id: 335283
Other names: N. eutropha C91, Nitrosomonas eutropha, Nitrosomonas eutropha C91, Nitrosomonas eutropha str. C91, Nitrosomonas eutropha strain C91
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