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ileS protein (Nitrosomonas eutropha) - STRING interaction network
"ileS" - Isoleucine--tRNA ligase in Nitrosomonas eutropha
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ileSIsoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as ’pretransfer’ editing and involves the hydrolysis of activated Val-AMP. The other activity is designated ’posttransfer’ editing and involves deacylation of mischarged Val-tRNA(Ile) (935 aa)    
Predicted Functional Partners:
Neut_1440
Riboflavin biosynthesis protein; KEGG- neu-NE1150 cytidylyltransferase-riboflavin kinase / FAD synthetase; TIGRFAM- riboflavin biosynthesis protein RibF; PFAM- Riboflavin kinase / FAD synthetase; cytidylyltransferase; Belongs to the ribF family (325 aa)
 
        0.977
lspA
Lipoprotein signal peptidase; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family (160 aa)
 
   
  0.973
leuS
Leucine--tRNA ligase; TIGRFAM- leucyl-tRNA synthetase; KEGG- neu-NE1139 t-RNA synthetase, class Ia-leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family (868 aa)
 
 
0.947
alaS
Alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction- alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (863 aa)
 
 
  0.918
proS
Proline--tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction- proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as ’pretransfer’ editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated ’posttransfer’ editing and involves deacy [...] (568 aa)
   
 
  0.917
valS
Valine--tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a "posttransfer" editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily (917 aa)
 
 
0.912
cysS
Cysteine--tRNA ligase; KEGG- neu-NE0043 cysteinyl-tRNA synthetase; TIGRFAM- cysteinyl-tRNA synthetase; PFAM- cysteinyl-tRNA synthetase, class Ia; Belongs to the class-I aminoacyl-tRNA synthetase family (467 aa)
     
   
  0.911
lysS
Lysine--tRNA ligase; TIGRFAM- lysyl-tRNA synthetase; PFAM- tRNA synthetase, class II (D, K and N); nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG- neu-NE2355 putative lysyl-tRNA synthetase protein; Belongs to the class-II aminoacyl-tRNA synthetase family (532 aa)
   
 
  0.901
purL
Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (1300 aa)
   
   
  0.894
pheT
Phenylalanine--tRNA ligase beta subunit; KEGG- neu-NE0953 phenylalanyl-tRNA synthetase beta chain protein; TIGRFAM- phenylalanyl-tRNA synthetase, beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily (792 aa)
   
 
  0.878
Your Current Organism:
Nitrosomonas eutropha
NCBI taxonomy Id: 335283
Other names: N. eutropha C91, Nitrosomonas eutropha, Nitrosomonas eutropha C91, Nitrosomonas eutropha str. C91, Nitrosomonas eutropha strain C91
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