Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Genes that are sometimes fused into single open reading frames.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
PFAM- protein of unknown function DUF484; KEGG- neu-NE0339 hypothetical protein (233 aa)
Predicted Functional Partners:
TIGRFAM- tyrosine recombinase XerC; PFAM- phage integrase family protein; phage integrase domain protein SAM domain protein; KEGG- neu-NE0338 phage integrase-phage integrase N-terminal SAM-like domain; Belongs to the ’phage’ integrase family. XerC subfamily (321 aa)
PFAM- Sporulation domain protein; KEGG- neu-NE0365 hypothetical protein (221 aa)
KEGG- neu-NE1137 putative DNA polymerase III (delta subunit) protein; TIGRFAM- DNA polymerase III, delta subunit; PFAM- DNA polymerase III, delta (357 aa)
TIGRFAM- TonB family protein; KEGG- neu-NE1626 putative TonB protein (276 aa)
KEGG- neu-NE0151 hypothetical protein (212 aa)
TIGRFAM- MJ0042 family finger-like protein; KEGG- neu-NE0655 hypothetical protein (250 aa)
Cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (95 aa)