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folD protein (Nitrosomonas eutropha) - STRING interaction network
"folD" - Bifunctional protein FolD in Nitrosomonas eutropha
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second shell of interactors
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some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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folDBifunctional protein FolD; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (295 aa)    
Predicted Functional Partners:
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (416 aa)
 
 
  0.994
gcvT
Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (363 aa)
   
 
  0.988
purH
Bifunctional purine biosynthesis protein PurH; KEGG- neu-NE0876 probable phosphoribosylaminoimidazolecarboxamide formyltransferase and IMP cyclodydrolase transmembrane protein; TIGRFAM- phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM- AICARFT/IMPCHase bienzyme; MGS domain protein (520 aa)
 
  0.983
fmt
Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus (316 aa)
 
  0.969
Neut_1891
KEGG- neu-NE0661 5,10-methylenetetrahydrofolate reductase oxidoreductase protein; TIGRFAM- 5,10-methylenetetrahydrofolate reductase; PFAM- methylenetetrahydrofolate reductase (284 aa)
   
 
  0.963
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate (210 aa)
 
 
  0.961
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2’-deoxyuridine- 5’-monophosphate (dUMP) to 2’-deoxythymidine-5’-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis (264 aa)
   
  0.926
Neut_0410
KEGG- neu-NE1951 adenylosuccinate lyase; TIGRFAM- adenylosuccinate lyase; PFAM- fumarate lyase; Adenylosuccinate lyase C-terminal domain protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily (458 aa)
   
 
  0.877
purL
Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (1300 aa)
   
   
  0.858
purD
Phosphoribosylamine--glycine ligase; KEGG- neu-NE0877 phosphoribosylglycinamide synthetase; TIGRFAM- phosphoribosylamine--glycine ligase; PFAM- phosphoribosylglycinamide synthetase; Belongs to the GARS family (432 aa)
 
   
  0.795
Your Current Organism:
Nitrosomonas eutropha
NCBI taxonomy Id: 335283
Other names: N. eutropha C91, Nitrosomonas eutropha, Nitrosomonas eutropha C91, Nitrosomonas eutropha str. C91, Nitrosomonas eutropha strain C91
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