• Version:
  • 11.0 (preview - - version 10.5 still available here)
STRINGSTRING
mdh protein (Nitrosomonas eutropha) - STRING interaction network
"mdh" - Malate dehydrogenase in Nitrosomonas eutropha
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate (327 aa)    
Predicted Functional Partners:
Neut_0861
KEGG- neu-NE2373 citrate synthase; TIGRFAM- citrate synthase I; PFAM- Citrate synthase; Belongs to the citrate synthase family (427 aa)
   
  0.993
fumC
Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily (466 aa)
   
  0.979
Neut_0596
Malate dehydrogenase (Oxaloacetate-decarboxylating) (NADP(+)); PFAM- malic enzyme domain protein; malic enzyme, NAD-binding; KEGG- neu-NE0438 putative malate oxidoreductase (malic enzyme) (536 aa)
   
  0.971
Neut_0605
Succinate--CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit (295 aa)
   
 
  0.970
ppc
Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (933 aa)
     
 
  0.951
Neut_0606
Succinate--CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit (390 aa)
   
  0.946
Neut_1083
PFAM- aminotransferase, class I and II; KEGG- neu-NE0786 aminotransferases class-I (397 aa)
   
 
  0.916
eno
Enolase; Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family (428 aa)
   
 
  0.883
Neut_0501
PFAM- Glu/Leu/Phe/Val dehydrogenase, C terminal; Glu/Leu/Phe/Val dehydrogenase, dimerisation region; KEGG- neu-NE1616 glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family (447 aa)
   
 
  0.880
Neut_2045
TIGRFAM- isocitrate dehydrogenase, NADP-dependent; PFAM- isocitrate/isopropylmalate dehydrogenase; KEGG- neu-NE1730 isocitrate dehydrogenase [NADP] oxidoreductase protein (415 aa)
   
 
  0.866
Your Current Organism:
Nitrosomonas eutropha
NCBI taxonomy Id: 335283
Other names: N. eutropha C91, Nitrosomonas eutropha, Nitrosomonas eutropha C91, Nitrosomonas eutropha str. C91, Nitrosomonas eutropha strain C91
Server load: low (7%) [HD]