node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Neut_0607 | Neut_0724 | Neut_0607 | Neut_0724 | Citryl-CoA lyase; PFAM: HpcH/HpaI aldolase; KEGG: neu:NE1809 probable beta subunit of citrate lyase; Belongs to the HpcH/HpaI aldolase family. | PFAM: Enoyl-CoA hydratase/isomerase; 3-hydroxyacyl-CoA dehydrogenase domain protein; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding; KEGG: neu:NE1528 putative 3-hydroxyacyl-CoA dehydrogenase oxidoreductase protein. | 0.409 |
Neut_0607 | Neut_1995 | Neut_0607 | Neut_1995 | Citryl-CoA lyase; PFAM: HpcH/HpaI aldolase; KEGG: neu:NE1809 probable beta subunit of citrate lyase; Belongs to the HpcH/HpaI aldolase family. | Phosphotransacetylase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. | 0.907 |
Neut_0607 | acsA | Neut_0607 | Neut_1690 | Citryl-CoA lyase; PFAM: HpcH/HpaI aldolase; KEGG: neu:NE1809 probable beta subunit of citrate lyase; Belongs to the HpcH/HpaI aldolase family. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.919 |
Neut_0607 | sucC-2 | Neut_0607 | Neut_0606 | Citryl-CoA lyase; PFAM: HpcH/HpaI aldolase; KEGG: neu:NE1809 probable beta subunit of citrate lyase; Belongs to the HpcH/HpaI aldolase family. | succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.959 |
Neut_0610 | Neut_0724 | Neut_0610 | Neut_0724 | KEGG: neu:NE2262 beta-ketothiolase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | PFAM: Enoyl-CoA hydratase/isomerase; 3-hydroxyacyl-CoA dehydrogenase domain protein; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding; KEGG: neu:NE1528 putative 3-hydroxyacyl-CoA dehydrogenase oxidoreductase protein. | 0.999 |
Neut_0610 | Neut_0861 | Neut_0610 | Neut_0861 | KEGG: neu:NE2262 beta-ketothiolase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | KEGG: neu:NE2373 citrate synthase; TIGRFAM: citrate synthase I; PFAM: Citrate synthase; Belongs to the citrate synthase family. | 0.936 |
Neut_0610 | Neut_1899 | Neut_0610 | Neut_1899 | KEGG: neu:NE2262 beta-ketothiolase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | acetyl-CoA carboxylase carboxyltransferase subunit alpha; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 0.914 |
Neut_0610 | Neut_1995 | Neut_0610 | Neut_1995 | KEGG: neu:NE2262 beta-ketothiolase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | Phosphotransacetylase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. | 0.947 |
Neut_0610 | accD | Neut_0610 | Neut_1154 | KEGG: neu:NE2262 beta-ketothiolase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | 0.909 |
Neut_0610 | acsA | Neut_0610 | Neut_1690 | KEGG: neu:NE2262 beta-ketothiolase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.949 |
Neut_0610 | leuA | Neut_0610 | Neut_1244 | KEGG: neu:NE2262 beta-ketothiolase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.934 |
Neut_0724 | Neut_0607 | Neut_0724 | Neut_0607 | PFAM: Enoyl-CoA hydratase/isomerase; 3-hydroxyacyl-CoA dehydrogenase domain protein; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding; KEGG: neu:NE1528 putative 3-hydroxyacyl-CoA dehydrogenase oxidoreductase protein. | Citryl-CoA lyase; PFAM: HpcH/HpaI aldolase; KEGG: neu:NE1809 probable beta subunit of citrate lyase; Belongs to the HpcH/HpaI aldolase family. | 0.409 |
Neut_0724 | Neut_0610 | Neut_0724 | Neut_0610 | PFAM: Enoyl-CoA hydratase/isomerase; 3-hydroxyacyl-CoA dehydrogenase domain protein; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding; KEGG: neu:NE1528 putative 3-hydroxyacyl-CoA dehydrogenase oxidoreductase protein. | KEGG: neu:NE2262 beta-ketothiolase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | 0.999 |
Neut_0724 | Neut_0861 | Neut_0724 | Neut_0861 | PFAM: Enoyl-CoA hydratase/isomerase; 3-hydroxyacyl-CoA dehydrogenase domain protein; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding; KEGG: neu:NE1528 putative 3-hydroxyacyl-CoA dehydrogenase oxidoreductase protein. | KEGG: neu:NE2373 citrate synthase; TIGRFAM: citrate synthase I; PFAM: Citrate synthase; Belongs to the citrate synthase family. | 0.864 |
Neut_0724 | Neut_1899 | Neut_0724 | Neut_1899 | PFAM: Enoyl-CoA hydratase/isomerase; 3-hydroxyacyl-CoA dehydrogenase domain protein; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding; KEGG: neu:NE1528 putative 3-hydroxyacyl-CoA dehydrogenase oxidoreductase protein. | acetyl-CoA carboxylase carboxyltransferase subunit alpha; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 0.489 |
Neut_0724 | Neut_1995 | Neut_0724 | Neut_1995 | PFAM: Enoyl-CoA hydratase/isomerase; 3-hydroxyacyl-CoA dehydrogenase domain protein; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding; KEGG: neu:NE1528 putative 3-hydroxyacyl-CoA dehydrogenase oxidoreductase protein. | Phosphotransacetylase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. | 0.619 |
Neut_0724 | accD | Neut_0724 | Neut_1154 | PFAM: Enoyl-CoA hydratase/isomerase; 3-hydroxyacyl-CoA dehydrogenase domain protein; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding; KEGG: neu:NE1528 putative 3-hydroxyacyl-CoA dehydrogenase oxidoreductase protein. | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | 0.498 |
Neut_0724 | ackA | Neut_0724 | Neut_2086 | PFAM: Enoyl-CoA hydratase/isomerase; 3-hydroxyacyl-CoA dehydrogenase domain protein; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding; KEGG: neu:NE1528 putative 3-hydroxyacyl-CoA dehydrogenase oxidoreductase protein. | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. | 0.495 |
Neut_0724 | acsA | Neut_0724 | Neut_1690 | PFAM: Enoyl-CoA hydratase/isomerase; 3-hydroxyacyl-CoA dehydrogenase domain protein; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding; KEGG: neu:NE1528 putative 3-hydroxyacyl-CoA dehydrogenase oxidoreductase protein. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.940 |
Neut_0724 | leuA | Neut_0724 | Neut_1244 | PFAM: Enoyl-CoA hydratase/isomerase; 3-hydroxyacyl-CoA dehydrogenase domain protein; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding; KEGG: neu:NE1528 putative 3-hydroxyacyl-CoA dehydrogenase oxidoreductase protein. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.692 |