• Version:
  • 11.0 (preview - - version 10.5 still available here)
STRINGSTRING
Neut_2295 protein (Nitrosomonas eutropha) - STRING interaction network
"Neut_2295" - KEGG: neu:NE0070 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase in Nitrosomonas eutropha
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Neut_2295KEGG- neu-NE0070 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; TIGRFAM- 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM- 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK (170 aa)    
Predicted Functional Partners:
Neut_0999
Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives (300 aa)
 
  0.998
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate; Belongs to the PanB family (269 aa)
   
  0.981
Neut_2294
PFAM- deoxynucleoside kinase; KEGG- neu-NE0071 deoxynucleoside kinase (214 aa)
            0.980
Neut_0294
PFAM- dihydroneopterin aldolase; KEGG- neu-NE0223 dihydroneopterin aldolase (117 aa)
 
 
  0.973
pcnB
Poly(A) polymerase I; Adds poly(A) tail to the 3’ end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control (462 aa)
   
   
  0.922
folE2
GTP cyclohydrolase FolE2; Converts GTP to 7,8-dihydroneopterin triphosphate (267 aa)
       
  0.922
Neut_1020
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (176 aa)
 
   
  0.906
panC
Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate; Belongs to the pantothenate synthetase family (277 aa)
 
   
  0.897
Neut_1155
TIGRFAM- FolC bifunctional protein; PFAM- cytoplasmic peptidoglycan synthetases domain protein; Mur ligase, middle domain protein; KEGG- neu-NE0696 cytoplasmic peptidoglycan synthetases, C-terminal; Belongs to the folylpolyglutamate synthase family (428 aa)
 
   
  0.883
acpS
Holo-[acyl-carrier-protein] synthase; Transfers the 4’-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family (125 aa)
          0.842
Your Current Organism:
Nitrosomonas eutropha
NCBI taxonomy Id: 335283
Other names: N. eutropha C91, Nitrosomonas eutropha, Nitrosomonas eutropha C91, Nitrosomonas eutropha str. C91, Nitrosomonas eutropha strain C91
Server load: low (7%) [HD]